{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T22:17:50Z","timestamp":1771539470956,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009033","name":"NHS Blood and Transplant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Aims\/Objectives<\/jats:title><jats:p>To explore the impact of Human Leucocyte Antigen (HLA)\u2010A and B epitope\u2010matched platelets on the outcome of platelet transfusions in alloimmunised patients with aplastic anaemia (AA). The relevance of HLA\u2010C epitope mismatches was also investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients who become immunologically refractory (IR) to random platelet transfusions can experience an adequate rise in platelet count through the provision of HLA\u2010compatible platelets using an antigen\u2010matching algorithm. This approach has been shown to be effective in patients with a low calculated reaction frequency, but it is not always successful in highly sensitised patients. The use of HLA epitopes\u2010selected platelets has been suggested as an alternative to the antigen matching approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The effect of HLA epitope matching (both Eplets and Triplets) on the outcome of platelet transfusion was analysed in 37 highly immunised AA patients previously transfused with HLA\u2010A and B antigen\u2010matched platelets. Epitope matching was determined using the HLAMatchmaker programme. The outcome of the transfusions was assessed by the platelet count increments (PCIs) obtained 1 and 24 hours post\u2010transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HLA\u2010A and B epitope matching was equivalent to HLA antigen matching in raising platelet counts. There was no significant difference in PCI when HLA\u2010C epitope mismatches were considered. In addition, transfusions with fewer than two antigen mismatches resulted in significantly higher PCIs compared to transfusions with more than two antigen mismatches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HLA epitope\u2010matched platelet provision may represent a clinically effective transfusion strategy for patients IR to random platelet transfusions. Further prospective studies are required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12612","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T02:08:11Z","timestamp":1560823691000},"page":"23-29","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Impact of Human Leucocyte Antigen epitope matched platelet transfusions in alloimmunised aplastic anaemia patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Delordson","family":"Kallon","sequence":"first","affiliation":[{"name":"Clinical Transplantation Laboratory Barts Health NHS Trust  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina V.","family":"Navarrete","sequence":"additional","affiliation":[{"name":"Histocompatibility and Immunogenetics Services National Health Service Blood and Transplant (NHSBT)  London UK"},{"name":"Division of Infection &amp; Immunity University College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah A.","family":"Sage","sequence":"additional","affiliation":[{"name":"Histocompatibility and Immunogenetics Services National Health Service Blood and Transplant (NHSBT)  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7414-4950","authenticated-orcid":false,"given":"Simon","family":"Stanworth","sequence":"additional","affiliation":[{"name":"Transfusion Medicine NHS Blood and Transplant  Oxford UK"},{"name":"Department of Haematology Oxford University Hospitals NHS Foundation Trust  Oxford UK"},{"name":"Radcliffe Department of Medicine University of Oxford  Oxford UK"},{"name":"Oxford BRC Haematology Theme  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam J.","family":"Mufti","sequence":"additional","affiliation":[{"name":"Department of Haematological Medicine King's College Hospital\/King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith C. W.","family":"Marsh","sequence":"additional","affiliation":[{"name":"Department of Haematological Medicine King's College Hospital\/King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5678-2799","authenticated-orcid":false,"given":"Colin J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Histocompatibility and Immunogenetics Services National Health Service Blood and Transplant (NHSBT)  London UK"},{"name":"Faculty of life Sciences and Medicine King's College London, University of London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31591263191.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V81.12.3428.3428"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199502060-00015"},{"key":"e_1_2_7_5_1","first-page":"1035","article-title":"Factors associated with response to platelet transfusion following hematopoietic stem cell transplantation","volume":"17","author":"Klumpp TR","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.03.005"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V51.5.781.781"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1994.34394196618.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1142\/9781848160507_0021"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.2000.7920108.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00051.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.10.003"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000055097.58209.83"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(02)00381-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000055101.20821.AC"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2006.08.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(02)00382-8"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2005.04.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1997.812721.x"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2007.00989.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-014-2868-6"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2010.79"},{"key":"e_1_2_7_23_1","volume-title":"Guidelines for the Blood Transfusion Services in the United Kingdom","author":"MacLennan S","year":"2013"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.5.1519"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830020303"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01837.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4080"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12409"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02703.x"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tme.12612","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T16:49:54Z","timestamp":1694018994000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/tme.12612"],"URL":"https:\/\/doi.org\/10.1111\/tme.12612","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2018-05-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}