{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:11:40Z","timestamp":1785427900731,"version":"3.56.0"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009033","name":"NHS Blood and Transplant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>SUMMARY<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate attrition at the finally selected donor stage among British Bone Marrow Registry (BBMR) donors, all recruited from blood donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The success of searches for unrelated stem cell donors relies on the existence of large international donor registries and the availability of registered donors when matched with a patient. Withdrawal of donors may adversely affect patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/Methods<\/jats:title><jats:p>Data on 2942 planned donations were analysed to assess donor\u2010related deferral rates and associated factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 20\u00b72% of requests were cancelled. Transplant centres activated more than half of the cancellations (52\u00b76%). Donor reasons accounted for 46\u00b77% of cancellations (9\u00b74% of requests), of which 61\u00b77% happened for medical and 38\u00b73% for personal reasons. Medical ineligibility of the donor was associated with increasing age (odds ratio [OR]\u00a0=\u00a01\u00b736, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7011) and peripheral blood stem cell source (OR\u00a0=\u00a02\u00b722, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7006), and there was some evidence of association with low blood donation reliability (OR\u00a0=\u00a01\u00b752, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7054). The blood donor reliability score relates to blood donation, and the score worsens if donors consistently fail to attend a donation session when invited. Withdrawal on personal grounds showed associations with donor age (OR\u00a0=\u00a01\u00b772, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7017, 30\u201340\u2009years vs other ages), peripheral blood stem cell source (OR\u00a0=\u00a02\u00b743, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7010) and low blood donor reliability (OR\u00a0=\u00a01\u00b794, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this is the first report on all\u2010cause cancellation at the finally\u2010selected donor stage for international stem cell donor provision, showing 9\u00b74% donor\u2010related cancellation rate. Scores associated with blood donation reliability may be useful to predict stem cell donor withdrawal.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12613","type":"journal-article","created":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T01:28:31Z","timestamp":1560821311000},"page":"332-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Attrition at the final donor stage among unrelated haematopoietic stem cell donors: the British Bone Marrow Registry experience"],"prefix":"10.1111","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5911-2440","authenticated-orcid":false,"given":"K.","family":"Balassa","sequence":"first","affiliation":[{"name":"British Bone Marrow Registry NHS Blood and Transplant  Bristol UK"},{"name":"Department of Clinical Haematology, Cancer and Haematology Centre Oxford University Hospitals NHS Foundation Trust  Oxford 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