{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T04:37:54Z","timestamp":1791434274761,"version":"4.3.3"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T00:00:00Z","timestamp":1576713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to assess abnormality of coagulation and anticoagulation parameters in dengue fever patients and the impact of these tests on the management of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Dengue fever is endemic in Pakistan with seasonal rise in cases. Morbidities and mortalities are proportionately reported to be increasing and associated with disseminated intravascular coagulation resulting in haemorrhagic or thrombotic manifestations in patients having deranged coagulation profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Materials<\/jats:title><jats:p>This observational and descriptive study was conducted on confirmed Dengue patients at the National Institute of Blood Diseases during the years 2013 to 2016. Patients of all age groups were included in this study. Results were analysed by SPSS version 23.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 200 patients were selected with the mean age being 28.68\u2009years (\u00b113.28) and male predominance (147\/200). The mean platelet count, haemoglobin and haematocrit at base line for bleeders and non\u2010bleeders showed significant results, where platelet count at baseline for bleeders was 24\u2009000, whereas for non\u2010bleeders it was 29\u2009000 and it showed significant correlation with bleeding (<jats:italic>P<\/jats:italic>\u2010value .027). Platelets were transfused to 76 (38%) patients. However, none of the specialised haemostasis parameters beside the platelet count correlated with bleeding, requiring platelet transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study showed a significant association of platelet counts, haemoglobin and haematocrit with bleeding. It can be concluded that coagulation and anticoagulation profiles will not benefit the management of dengue patients and in countries like Pakistan, it will only add to the economic burden on the patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12658","type":"journal-article","created":{"date-parts":[[2019,12,19]],"date-time":"2019-12-19T08:41:05Z","timestamp":1576744865000},"page":"46-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Coagulation abnormalities in dengue and dengue haemorrhagic fever patients"],"prefix":"10.1111","volume":"30","author":[{"given":"Jawad","family":"Hassan","sequence":"first","affiliation":[{"name":"Department of Hematology, Hemostasis &amp; Thrombosis National Institute of Blood Disease &amp; Bone Marrow Transplantation  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7867-1275","authenticated-orcid":false,"given":"Munira","family":"Borhany","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemostasis &amp; Thrombosis National Institute of Blood Disease &amp; Bone Marrow Transplantation  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madiha","family":"Abid","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemostasis &amp; Thrombosis National Institute of Blood Disease &amp; Bone Marrow Transplantation  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzma","family":"Zaidi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemostasis &amp; Thrombosis National Institute of Blood Disease &amp; Bone Marrow Transplantation  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naveena","family":"Fatima","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemostasis &amp; Thrombosis National Institute of Blood Disease &amp; Bone Marrow Transplantation  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahir","family":"Shamsi","sequence":"additional","affiliation":[{"name":"Department of Hematology, Hemostasis &amp; Thrombosis National Institute of Blood Disease &amp; Bone Marrow Transplantation  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,12,19]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2460"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(01)00171-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cimid.2004.03.013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2009.08-0008"},{"key":"e_1_2_9_6_1","volume-title":"Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control","author":"Organization WH, Research SPf, Diseases TiT, Diseases WHODoCoNT, Epidemic WHO, Alert P","year":"2009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012505"},{"key":"e_1_2_9_8_1","unstructured":"NimmannityaS. 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