{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:15:11Z","timestamp":1768637711057,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010377","name":"National Institute for Health and Care Excellence","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previously, routine antenatal anti\u2010D prophylaxis (RAADP) was administered to all RhD\u2010negative mothers to reduce the risk of sensitisation in the UK's National Health Service (NHS). If the baby is RhD\u2010negative, RAADP is not required. In 2016, the UK National Institute for Health and Care Excellence (NICE) recommended non\u2010invasive prenatal testing (NIPT) for fetal <jats:italic>RHD<\/jats:italic> genotype as a cost\u2010effective option to guide RAADP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the implementation of high\u2010throughput NIPT for fetal <jats:italic>RHD<\/jats:italic> genotype in maternity units in England by addressing research recommendations from the NICE. These were to reduce uncertainty around the resource use and cost of staff training, management of samples and results and record\u2010keeping, as well as resultant changes to antenatal or post\u2010partum care and performance of NIPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional survey was developed and sent to clinicians at 39 English NHS Trusts in May 2018. Qualitative interviews with seven individuals were conducted to explore missing or contraindicatory data. Qualitative findings were supplemented with NIPT test results (April 2017 to February 2019) from English hospitals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Staff reported that training took up to 30\u2009minutes. There were no extra costs associated with sample management or additional appointments. Extra time required for record\u2010keeping and management of test results was balanced later in the patient pathway. The antenatal pathway was not changed in the Trusts surveyed. The survey revealed that four post\u2010partum scenarios were being used within English NHS Trusts. The frequency of inconclusive NIPT results was 4.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NIPT for fetal <jats:italic>RHD<\/jats:italic> genotype can be implemented without consuming substantial extra resources through incorporation into an existing patient pathway.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12702","type":"journal-article","created":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T08:58:40Z","timestamp":1590310720000},"page":"287-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Implementation of high\u2010throughput non\u2010invasive prenatal testing for fetal <scp><i>RHD<\/i><\/scp> genotype testing in England: Results of a cross\u2010sectional survey of maternity units and expert interviews"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8394-5066","authenticated-orcid":false,"given":"Edyta","family":"Ryczek","sequence":"first","affiliation":[{"name":"Cedar, Cardiff and Vale University Health Board, Cardiff Medicentre Heath Park  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"White","sequence":"additional","affiliation":[{"name":"Cedar, Cardiff and Vale University Health Board, Cardiff Medicentre Heath Park  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Carolan\u2010Rees","sequence":"additional","affiliation":[{"name":"Cedar, Cardiff and Vale University Health Board, Cardiff Medicentre Heath Park  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,6,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1054\/blre.1999.0123"},{"key":"e_1_2_7_3_1","unstructured":"National Institute for Health and Clinical Excellence. Routine antenatal anti\u2010D prophylaxis for women who are rhesus D negative. NICE technology appraisal guidance 156.https:\/\/www.nice.org.uk\/guidance\/ta56Published 2008. Accessed October 29 2019."},{"key":"e_1_2_7_4_1","unstructured":"National Institute for Health and Care Excellence. High\u2010throughput non\u2010invasive prenatal testing for foetal RHD genotype. NICE diagnostic guidance 25.https:\/\/www.nice.org.uk\/guidance\/dg25Published2016. Accessed October 29 2019."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g5243"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e31825d33d9"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1609406917733847"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"e_1_2_7_9_1","unstructured":"Critical Appraisal Skills Programme. CASP qualitative checklist.https:\/\/casp-uk.net\/wp-content\/uploads\/2018\/01\/CASP-Qualitative-Checklist-2018.pdf. Published2018. Accessed December 29 2019."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13055"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3310\/hta22130"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftme.12702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tme.12702","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T09:11:28Z","timestamp":1693905088000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,11]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1111\/tme.12702"],"URL":"https:\/\/doi.org\/10.1111\/tme.12702","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,11]]},"assertion":[{"value":"2019-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}