{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:57:16Z","timestamp":1787061436260,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T00:00:00Z","timestamp":1608422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/18\/13\/33946"],"award-info":[{"award-number":["RG\/18\/13\/33946"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["RG\/13\/13\/30194"],"award-info":[{"award-number":["RG\/13\/13\/30194"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To compare four haemoglobin measurement methods in whole blood donors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To safeguard donors, blood services measure haemoglobin concentration in advance of each donation. NHS Blood and Transplant's (NHSBT) customary method have been capillary gravimetry (copper sulphate), followed by venous spectrophotometry (HemoCue) for donors failing gravimetry. However, NHSBT's customary method results in 10% of donors being inappropriately bled (ie, with haemoglobin values below the regulatory threshold).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We compared the following four methods in 21\u2009840 blood donors (aged \u226518\u2009years) recruited from 10 NHSBT centres in England, with the Sysmex XN\u20102000 haematology analyser, the reference standard: (1) NHSBT's customary method; (2) \u201cpost donation\u201d approach, that is, estimating current haemoglobin concentration from that measured by a haematology analyser at a donor's most recent prior donation; (3) \u201cportable haemoglobinometry\u201d (using capillary HemoCue); (4) non\u2010invasive spectrometry (using MBR Haemospect or Orsense NMB200). We assessed sensitivity; specificity; proportion who would have been inappropriately bled, or rejected from donation (\u201cdeferred\u201d) incorrectly; and test preference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Compared with the reference standard, the methods ranged in test sensitivity from 17.0% (MBR Haemospect) to 79.0% (portable haemoglobinometry) in men, and from 19.0% (MBR Haemospect) to 82.8% (portable haemoglobinometry) in women. For specificity, the methods ranged from 87.2% (MBR Haemospect) to 99.9% (NHSBT's customary method) in men, and from 74.1% (Orsense NMB200) to 99.8% (NHSBT's customary method) in women. The proportion of donors who would have been inappropriately bled ranged from 2.2% in men for portable haemoglobinometry to 18.9% in women for MBR Haemospect. The proportion of donors who would have been deferred incorrectly with haemoglobin concentration above the minimum threshold ranged from 0.1% in men for NHSBT's customary method to 20.3% in women for OrSense. Most donors preferred non\u2010invasive spectrometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In the largest study reporting head\u2010to\u2010head comparisons of four methods to measure haemoglobin prior to blood donation, our results support replacement of NHSBT's customary method with portable haemoglobinometry.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.12750","type":"journal-article","created":{"date-parts":[[2020,12,20]],"date-time":"2020-12-20T18:47:16Z","timestamp":1608490036000},"page":"94-103","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Comparison of four methods to measure haemoglobin concentrations in whole blood donors (\n                    <scp>COMPARE<\/scp>\n                    ): A diagnostic accuracy study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6774-3149","authenticated-orcid":false,"given":"Steven","family":"Bell","sequence":"first","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0980-8965","authenticated-orcid":false,"given":"Michael","family":"Sweeting","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"},{"name":"Department of Health Sciences University of Leicester  Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9958-3693","authenticated-orcid":false,"given":"Anna","family":"Ramond","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Kaptoge","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bolton","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Sambrook","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant  London, Oxford, Cambridge UK"},{"name":"Department of Haematology University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"},{"name":"Anglia Ruskin University  Chelmsford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"McMahon","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-9952","authenticated-orcid":false,"given":"Sarah","family":"Fahle","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Cullen","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant  London, Oxford, Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Mehenny","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant  London, Oxford, Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7937-304X","authenticated-orcid":false,"given":"Angela M.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8691-9226","authenticated-orcid":false,"given":"Jane","family":"Armitage","sequence":"additional","affiliation":[{"name":"Nuffield Department of Population Health University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7744-1790","authenticated-orcid":false,"given":"Willem H.","family":"Ouwehand","sequence":"additional","affiliation":[{"name":"Department of Public Health and Primary Care University of Cambridge  Cambridge UK"},{"name":"NHS Blood and Transplant  London, Oxford, Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gail","family":"Miflin","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant  London, Oxford, Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Roberts","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant  London, Oxford, Cambridge UK"},{"name":"Radcliffe Department of Medicine and BRC Biomedical Centre \u2013 Haematology Theme, John Radcliffe Hospital University of Oxford  Oxford 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