{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:02:13Z","timestamp":1770836533030,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To reduce the risk of RhD alloimmunization during the last trimester of pregnancy, a targeted routine antenatal anti\u2010D prophylaxis (RAADP) programme was implemented in Norway in 2016. Here, we present and discuss our experience with the nationwide implementation of the programme, and report sample uptake and preliminary data of de novo anti\u2010D in pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The targeted RAADP was advised by the academic community and evaluated by the health authorities. A National Working Group has conducted the implementation in the transfusion services and contributed to organise the administration of the antenatal anti\u2010D prophylaxis. Fetal RhD type is determined by non\u2010invasive prenatal testing at gestational week 24, and anti\u2010D prophylaxis is administrated at gestational week 28 only to women with RhD positive fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We describe the implementation process of targeted RAADP in Norway. The sample uptake is calculated by comparing the number of fetal <jats:italic>RHD<\/jats:italic> screens with the expected number of samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample uptake shows regional variations: 88%\u2013100% after 3\u2009years. Promising decrease in de novo anti\u2010D detected during pregnancy is observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Nationwide targeted RAADP is implemented and included in the Norwegian maternity care programme. Compliance to sample uptake should further improve in some regions. A remaining issue to fulfil is the documentation of the accuracy of the fetal <jats:italic>RHD<\/jats:italic>\u2010typing at all sites. Post\u2010natal prophylaxis will then be guided by the fetal <jats:italic>RHD<\/jats:italic> result. Dedicated registries will ensure data to evaluate the expected reduction in pregnancy\u2010related RhD immunisations, which is the final success criterion of the programme.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12772","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T02:14:50Z","timestamp":1617675290000},"page":"314-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Norwegian experience with nationwide implementation of fetal <scp><i>RHD<\/i><\/scp> genotyping and targeted routine antenatal <scp>anti\u2010D<\/scp> prophylaxis"],"prefix":"10.1111","volume":"31","author":[{"given":"Kirsten","family":"S\u00f8rensen","sequence":"first","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette S.","family":"B\u00e6vre","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geir","family":"Tomter","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abid Hussain","family":"Llohn","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Akershus University Hospital  L\u00f8renskog Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin G.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Haukeland University Hospital  Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurora","family":"Espinosa","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbora","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine St. Olav University Hospital  Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirajana Grujic","family":"Arsenovic","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingvild Hausberg","family":"S\u00f8rvoll","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine University Hospital of North Norway  Troms\u00f8 Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aud Norunn","family":"Ulvahaug","sequence":"additional","affiliation":[{"name":"Transfusion service Vestfold Hospital  T\u00f8nsberg Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Sundic","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Stavanger University Hospital  Stavanger Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7i\u011fdem Akal\u0131n","family":"Akk\u00f6k","sequence":"additional","affiliation":[{"name":"Department of Immunology and Transfusion Medicine Oslo University Hospital  Oslo Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2018.1475681"},{"key":"e_1_2_6_3_1","unstructured":"The Directorate of Health.Veileder for transfusjonstjenesten i Norge utgave 7.3 (National guidelines for transfusion medicine services in Norway ed. 7.3);2017."},{"issue":"2","key":"e_1_2_6_4_1","article-title":"Anti\u2010D administration after childbirth for preventing rhesus alloimmunisation","volume":"1997","author":"Crowther C","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_5_1","unstructured":"Norwegian Society of Gynecology and Obstetrics (Norsk gynekologisk forening).Veileder i f\u00f8dselshjelp \u2010 Alloimmunisering mot erytrocytt\u2010antigener (The Norwegian national guidelines for obstetrics \u2010RBC alloimmunization);2020.https:\/\/www.legeforeningen.no\/foreningsledd\/fagmed\/norsk\u2010gynekologisk\u2010forening\/veiledere\/veileder\u2010i\u2010fodselshjelp\u20102020\/alloimmunisering\u2010mot\u2010erytrocytt\u2010antigener\/."},{"key":"e_1_2_6_6_1","unstructured":"Bioteknologir\u00e5det (The Norwegian Biotechnology Advisory Board).Rhesus D\u2010typing av fosteret basert p\u00e5 fritt foster\u2010DNA i den gravides blod;2014.http:\/\/www.bioteknologiradet.no\/filarkiv\/2014\/05\/Helsedir-NIPD-RhD.pdf."},{"key":"e_1_2_6_7_1","volume-title":"NIPH Systematic Reviews. 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