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The objective of this study was to describe prophylactic TXA use in non\u2010cardiac surgeries at high risk for transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective cohort study of all adult patients undergoing major non\u2010cardiac surgery at \u22655% risk of perioperative transfusion at five Canadian hospitals between January 2014 and December 2016. Canadian Classification of Health Interventions procedure codes within the Discharge Abstract Database were linked to transfusion and laboratory databases. TXA use was ascertained electronically from The Ottawa Hospital Data Warehouse and via manual chart review for Winnipeg hospitals. For each surgery, we evaluated the percentage of patients who received TXA as well as the specifics of TXA dosing and administration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TXA use was evaluable in 14\u2009300 patients. Overall, 17% of surgeries received TXA, ranging from 0% to 68% among individual surgeries. TXA use was more common in orthopaedic (<jats:italic>n<\/jats:italic>\u00a0=\u00a02043\/4942; 41%) and spine surgeries (n\u00a0=\u00a0239\/1322; 18%) compared to other surgical domains (n\u00a0=\u00a0109\/8036; 1%). TXA was commonly administered as a bolus (n\u00a0=\u00a02097\/2391; 88%). The median TXA dose was 1000\u2009mg (IQR 1000\u20131000\u2009mg).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TXA is predominantly used in orthopaedic and spine surgeries, with little uptake in other non\u2010cardiac surgeries at high risk for red blood cell transfusion. Further studies are needed to evaluate the effectiveness and safety of TXA and to understand the barriers to TXA administration in a broad range of non\u2010cardiac surgeries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12780","type":"journal-article","created":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T03:49:07Z","timestamp":1620013747000},"page":"236-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Prophylactic tranexamic acid use in non\u2010cardiac surgeries at high risk for transfusion"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8776-4083","authenticated-orcid":false,"given":"Brett L.","family":"Houston","sequence":"first","affiliation":[{"name":"Department of Medical Oncology and Hematology CancerCare Manitoba  Winnipeg Manitoba Canada"},{"name":"Department of Internal Medicine University of Manitoba  Winnipeg Manitoba Canada"},{"name":"College of 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