{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:09:30Z","timestamp":1761491370864,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate the frequency of iron deficiency (ID) and anaemia in blood donors in Iceland and the impact of serum ferritin (SF) testing policy change.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Blood donations contribute to ID and\/or anaemia in whole blood donors (WBD). SF may be used to monitor blood donor iron stores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The study included WBD and new donors (ND) in the Icelandic Blood Bank in 1997\u20132019. SF was measured for ND and intermittently for WBD until October 2017, but thereafter for all WBD and ND at every visit. In January 2018, the SF threshold increased from 14 to 16\u2009\u03bcg\/L for ND and from 8 to 10\u00a0\u03bcg\/L for WBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 85\u2009370 SF results from 243\u2009369 visits of 32\u2009910 donors. Median SF was higher for males than females, both for ND (88.0 vs. 31.2\u2009\u03bcg\/L,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and WBD (before 2018: 43.0 vs. 22.0\u2009\u03bcg\/L,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). After the policy change in 2018, median SF increased for both male WBD (to 45.2\u00a0\u03bcg\/L,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and female WBD (to 25.7\u00a0\u03bcg\/L,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). ID (SF &lt;15\u2009\u03bcg\/L) was present in 10.6% of female ND and 0.5% of male ND. After policy change, the proportion of WB donations associated with ID decreased for males (from 6.4% to 4.0%) and females (from 18.9% to 14.1%). ID anaemia was present at some time in 3.7% of female WBD and 1.2% of male WBD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This nationwide study showed that ID in WB donors is common, especially among females, but monitoring SF may improve donor management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12856","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T07:42:24Z","timestamp":1645774944000},"page":"128-134","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Monitoring iron stores in Icelandic blood donors from 1997 through 2019"],"prefix":"10.1111","volume":"32","author":[{"given":"Erla","family":"Gestsdottir","sequence":"first","affiliation":[{"name":"Department of Medicine, Faculty of Medicine University of Iceland Reykjav\u00edk Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magnus Karl","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine University of Iceland Reykjav\u00edk Iceland"},{"name":"deCODE genetics\/Amgen Inc. Reykjav\u00edk Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigrun Helga","family":"Lund","sequence":"additional","affiliation":[{"name":"deCODE genetics\/Amgen Inc. Reykjav\u00edk Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vigdis","family":"Johannsdottir","sequence":"additional","affiliation":[{"name":"The Blood Bank Landspitali \u2013 The National University Hospital of Iceland Reykjav\u00edk Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorbj\u00f6rn","family":"Jonsson","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine University of Iceland Reykjav\u00edk Iceland"},{"name":"The Blood Bank Landspitali \u2013 The National University Hospital of Iceland Reykjav\u00edk Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sveinn","family":"Gudmundsson","sequence":"additional","affiliation":[{"name":"The Blood Bank Landspitali \u2013 The National University Hospital of Iceland Reykjav\u00edk Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3800-1223","authenticated-orcid":false,"given":"Anna Margret","family":"Halldorsdottir","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine University of Iceland Reykjav\u00edk Iceland"},{"name":"The Blood Bank Landspitali \u2013 The National University Hospital of Iceland Reykjav\u00edk Iceland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15282"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2014.10.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0421"},{"volume-title":"Guideline on use of ferritin concentrations to assess iron status in individuals and populations","year":"2020","author":"WHO","key":"e_1_2_8_5_1"},{"key":"e_1_2_8_6_1","unstructured":"Group AHI\u2010DW.AABB Donor Iron Deficiency Risk\u2010Based Decision\u2010Making Assessment Report Supplemental Material. Accessed June 19 2020.https:\/\/www.aabb.org\/tm\/Documents\/AABB-Donor-Iron-Deficiency-RBDM-Assessment-Report-Supplemental-Material.pdf.%202018.%20Accessed%2019.2018."},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02865.x"},{"issue":"6","key":"e_1_2_8_8_1","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1111\/trf.13522","article-title":"Blood donors in Iceland: a nationwide population\u2010based study from 2005 to 2013","volume":"56","author":"Johannsdottir V","year":"2016","journal-title":"Transfusion"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15179"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15133"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12518"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.06.028"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03062.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12554"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.119"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13956"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13152"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12431"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12856","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tme.12856","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T02:24:46Z","timestamp":1700274286000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,24]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1111\/tme.12856"],"URL":"https:\/\/doi.org\/10.1111\/tme.12856","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"type":"print","value":"0958-7578"},{"type":"electronic","value":"1365-3148"}],"subject":[],"published":{"date-parts":[[2022,2,24]]},"assertion":[{"value":"2021-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}