{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T12:44:25Z","timestamp":1787921065441,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T00:00:00Z","timestamp":1652054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies revealed the glucose\u20106\u2010phosphate dehydrogenase (G\u20106\u2010PD) deficiency prevalence of 7.7\u201310% among Thai blood donors. Transfusion of red blood cells (RBCs) from these subjects potentially causes haemolysis in recipients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>RBC units from the National Blood Centre were sampled to assess G\u20106\u2010PD levels using spectrophotometry. Patients with pure underproduction anaemia requiring blood transfusion were randomised to receive G\u20106\u2010PD\u2010deficient versus normal ABO\u2010matched RBCs. Pre\u2010 and 48\u2010h post\u2010transfusion indirect bilirubin, haemoglobin, haematocrit, lactate dehydrogenase (LDH) and haptoglobin were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From April 2020 to March 2021, 374 RBC units were tested for G\u20106\u2010PD, and that 25 were found to be G\u20106\u2010PD deficient. Twelve units of G\u20106\u2010PD\u2010deficient RBCs and 14 units of normal RBCs were given to patients who met the inclusion criteria. The median (interquartile range) increases of indirect bilirubin in G\u20106\u2010PD\u2010deficient (<jats:italic>N<\/jats:italic>\u00a0=\u00a011) versus normal RBCs (<jats:italic>N<\/jats:italic>\u00a0=\u00a013) were\u2009+\u20090.12 (0.27) versus\u2009+\u20090.01 (1.3) mg\/dl, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.030), respectively. The median increases of haemoglobin were 1.00 (0.50) versus\u2009+\u20090.80 (0.95), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.910, respectively. The increases in haematocrit were 2.59 (1.9) versus 2.29 (2.1), <jats:italic>p<\/jats:italic>\u00a0=\u00a00.733, respectively. There were no significant differences in changes of LDH and haptoglobin levels and no transfusion reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>G\u20106\u2010PD\u2010deficient packed red cells were associated with mildly elevated indirect bilirubin after transfusion, but there was no observed clinical symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12871","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T03:41:11Z","timestamp":1652154071000},"page":"293-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Randomised controlled trial of glucose\u20106\u2010phosphate dehydrogenase deficient versus non\u2010deficient red blood cell transfusion in patients with hypoproliferative anaemia"],"prefix":"10.1111","volume":"32","author":[{"given":"Suphattharachai","family":"Krajibthong","sequence":"first","affiliation":[{"name":"Division of Hematology, Department of Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vachiraphan","family":"Sahntipurna","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Unit King Chulalongkorn Memorial Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chalisa","family":"Parnsamut","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrawadee","family":"Pitakpolrat","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Faculty of Medicine Chulalongkorn University  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walaporn","family":"Pattanapongsak","sequence":"additional","affiliation":[{"name":"National Blood Centre Thai Red 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