{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T21:52:23Z","timestamp":1759009943230},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C49297\/A27294"],"award-info":[{"award-number":["C49297\/A27294"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Assess the prognostic value of pre\u2010operative haemoglobin concentration (Hb) for identifying patients who develop severe post\u2010operative anaemia or require blood transfusion following primary total hip or knee, or unicompartmental knee arthroplasty (THA, TKA, UKA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Pre\u2010operative group and save (G&amp;S), and post\u2010operative Hb measurement may be unnecessary for many patients undergoing hip and knee arthroplasty provided individuals at greatest risk of severe post\u2010operative anaemia can be identified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Patients undergoing THA, TKA, or UKA between 2011 and 2018 were included. Outcomes were post\u2010operative Hb below 70 and 80\u2009g\/L, and peri\u2010operative blood transfusion. Logistic regression assessed the association between pre\u2010operative Hb and each outcome. Decision curve analysis compared strategies for selecting patients for G&amp;S and post\u2010operative Hb measurement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>10 015 THA, TKA and UKA procedures were performed in 8582 patients. The incidence of blood transfusion (4.5%) decreased during the study. Using procedure specific Hb thresholds to select patients for pre\u2010operative G&amp;S and post\u2010operative Hb testing had a greater net benefit than selecting all patients, no patients, or patients with pre\u2010operative anaemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010operative G&amp;S and post\u2010operative Hb measurement may not be indicated for UKA or TKA when adopting restrictive transfusion thresholds, provided clinicians accept a 0.1% risk of patients developing severe undiagnosed post\u2010operative anaemia (Hb\u2009&lt;\u200970\u2009g\/L). The decision to perform these blood tests for THA patients should be based on local institutional data and selection of acceptable risk thresholds.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12873","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T11:42:59Z","timestamp":1652269379000},"page":"306-317","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Utility of pre\u2010operative haemoglobin concentration to guide peri\u2010operative blood tests for hip and knee arthroplasty: A decision curve analysis"],"prefix":"10.1111","volume":"32","author":[{"given":"Paula","family":"Dhiman","sequence":"first","affiliation":[{"name":"Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford  Oxford UK"},{"name":"NIHR Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria N.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Botnar Research Centre  Oxford UK"},{"name":"Nuffield Orthopaedic Centre  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary S.","family":"Collins","sequence":"additional","affiliation":[{"name":"Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences University of Oxford  Oxford UK"},{"name":"NIHR Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Van Calster","sequence":"additional","affiliation":[{"name":"Department of Development and Regeneration KU Leuven  Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gardash","family":"Bakhishli","sequence":"additional","affiliation":[{"name":"Oxford University Hospitals NHS Foundation Trust, Blood Safety and Conservation Team John Radcliffe Hospital  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George","family":"Grammatopoulos","sequence":"additional","affiliation":[{"name":"Division of Orthopaedic Surgery The Ottawa Hospital  Ottawa Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J.","family":"Price","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Botnar Research Centre  Oxford UK"},{"name":"Nuffield Orthopaedic Centre  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Taylor","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Botnar Research Centre  Oxford UK"},{"name":"Nuffield Orthopaedic Centre  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike F.","family":"Murphy","sequence":"additional","affiliation":[{"name":"NIHR Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust  Oxford UK"},{"name":"NHS Blood &amp; Transplant John Radcliffe Hospital  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben J. L.","family":"Kendrick","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Botnar Research Centre  Oxford UK"},{"name":"Nuffield Orthopaedic Centre  Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony J. R.","family":"Palmer","sequence":"additional","affiliation":[{"name":"Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences Botnar Research Centre  Oxford UK"},{"name":"Royal National Orthopaedic Hospital  Middlesex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/1120700018757940"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.05.008"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.01617"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31777-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32344-4"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.101B9.BJJ-2018-1096.R1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jisakos-2017-000168"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12332"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14372"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/anae.15056"},{"key":"e_1_2_6_12_1","unstructured":"National Institute for Health and Care Excellence.Blood transfusion (NICE guideline No. 24 [NG24]).https:\/\/www.nice.org.uk\/guidance\/ng24. 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