{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T11:49:59Z","timestamp":1780487399273,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T00:00:00Z","timestamp":1666051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Plasma is a commonly used blood product and is available in the form of fresh frozen plasma (FFP) or pooled solvent\/detergent\u2010treated plasma. In the Netherlands, solvent\/detergent\u2010treated plasma has become the standard product in the adult population since several years, but for neonatal use, FFP remains the product of preference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Description<\/jats:title><jats:p>A preterm neonate developed lung bleeding at day 8 postpartum, for which intubation and mechanical ventilation was required and transfusions with packed red blood cells and plasma, in the form of FFP, were given. Five hours after transfusion, a red discoloration of the urine occurred. An acute haemolytic transfusion was suspected, confirmed by laboratory investigations (fast decrease in haemoglobin, increased free haemoglobin, decreased haptoglobin, increased lactate dehydrogenase and a positive direct antiglobulin test [IgG 2+]). Additional research showed that the FFP product contained nonspecific auto\u2010antibodies that reacted with the transfused erythrocytes, most test erythrocytes and the donor's own erythrocytes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A neonate experienced an acute haemolytic reaction, most probably caused by administrating a FFP product containing auto\u2010antibodies. If transfused with solvent\/detergent\u2010treated plasma, such antibodies would have been diluted or captured. This case adds a new argument to the discussion on expanding the use of solvent\/detergent\u2010treated plasma to the paediatric population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12926","type":"journal-article","created":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:15:01Z","timestamp":1666138501000},"page":"174-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute haemolytic transfusion reaction after transfusion of fresh frozen plasma in a neonate\u2014Preventable by using solvent\/detergent\u2010treated pooled plasma?"],"prefix":"10.1111","volume":"33","author":[{"given":"Linda M.","family":"Henricks","sequence":"first","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise J.","family":"Huisman","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Sophia Children's Hospital, Erasmus University Medical Center  Rotterdam the Netherlands"},{"name":"Department of Transfusion Medicine Sanquin  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessie S.","family":"Luken","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services  Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masja","family":"de Haas","sequence":"additional","affiliation":[{"name":"Department of Immunohematology Diagnostics Sanquin Diagnostic Services  Amsterdam the Netherlands"},{"name":"Department of Hematology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia S.","family":"Ootjers","sequence":"additional","affiliation":[{"name":"Department of Hematology Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjan","family":"Albersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry and Laboratory Medicine Leiden University Medical Center  Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2016.01.003"},{"key":"e_1_2_5_3_1","unstructured":"TRIP foundation (Transfusion and Transplantation Reaction in Patients).TRIP report 2019 hemovigilance extended version. 2019."},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2008.05.005"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PCC.0000000000001149"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2020.00572"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3148.2006.00626.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1076029618774145"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.01.001"},{"key":"e_1_2_5_10_1","volume-title":"Product Information Omniplasma 45\u201370 mg\/Ml Solution for Infusion","author":"Octapharma GmbH","year":"2021"},{"key":"e_1_2_5_11_1","unstructured":"Canadian Agency for Drugs and Technologies in Health (CADTH).CADTH Technology Report. Octaplas compared with fresh frozen plasma to reduce the risk of transmitting lipid\u2010enevloped viruses: an economic analysis and budget impact analysis. 2011."},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.5.1651.1651"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.07.001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.13979.1"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14233"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9113789"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12573"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2003.048264"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/ajts.AJTS_57_16"},{"key":"e_1_2_5_20_1","unstructured":"Joint United Kingdom Blood Transfusion and Tissue Transplantation Services Professional Advisory Committee.Transfusion Handboek 10.2 Neonatal tranfusion. Accessed February 15 2022."}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tme.12926","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T20:49:48Z","timestamp":1692650988000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,18]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/tme.12926"],"URL":"https:\/\/doi.org\/10.1111\/tme.12926","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,18]]},"assertion":[{"value":"2022-06-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}