{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:58:06Z","timestamp":1761649086729},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T00:00:00Z","timestamp":1667952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Haemorrhage and coagulation disorders are common complications in cirrhotic patients, which cause blood products transfusion, and mounting evidence suggested that red blood cells (RBCs) were associated with pathologic thrombosis and RBC transfusion increased the risk of venous thromboembolism (VTE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The aim of the study was to investigate the association of RBC transfusion with splanchnic vein thrombosis (SVT) in cirrhotic patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials &amp; Methods<\/jats:title><jats:p>We retrospectively reviewed patients with cirrhosis admitted in the Hunan Provincial People's Hospital between January 2010 and September 2020. Demographic data, the development of SVT, blood transfusion product type and RBC transfusion dose were collected. Multivariate logistic regression analyses and propensity matching analysis (PSM) were performed to identify the association between RBC transfusion and development of SVT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 4479 patients with cirrhosis were enrolled in the study. SVT occurred in 48 (12.4%) cirrhotic patients in RBC transfusion group, and 233 (5.7%) cirrhotic patients in non\u2010RBC transfusion group. RBC transfusion was significantly associated with an increased risk of SVT (unadjusted odds ratio [OR] 2.345, 95% confidence interval [CI] 1.686\u20133.262, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Notably, this association remained robust after PSM, and the volume of RBC transfusion was associated with SVT in a dose\u2010dependent manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggested that RBC transfusion was associated with an increased risk of SVT in cirrhotic patients. High quality clinical study will be needed to further validate the association between RBC transfusion and SVT.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12937","type":"journal-article","created":{"date-parts":[[2022,11,9]],"date-time":"2022-11-09T10:20:57Z","timestamp":1667989257000},"page":"61-67","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Red blood cell transfusion is associated with an increased risk of splanchnic vein thrombosis in patients with cirrhosis"],"prefix":"10.1111","volume":"33","author":[{"given":"Guanghua","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha China"},{"name":"Laboratory of Hematology, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chushu","family":"Liao","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kangle","family":"Huang","sequence":"additional","affiliation":[{"name":"Laboratory of Hematology, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingqian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youde","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Hunan Provincial People's Hospital The First Affiliated Hospital of Hunan Normal University  Changsha 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