{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:51:27Z","timestamp":1769921487324,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T00:00:00Z","timestamp":1668470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report a rare case of acute hemolytic transfusion reaction (AHTR) following an ABO plasma incompatible group B platelet transfusion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>AHTR is an uncommon, but potentially fatal event. Most reported cases of platelet transfusions associated with AHTR involve group O donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 34\u2010year\u2010old man, recipient of a group AB haploidentical haematopoietic stem cell transplantation (HSCT), had received re\u2010induction chemotherapy for leukaemia relapse. A group B whole blood\u2010derived buffy coat platelet pool was transfused. He developed rigours\/fever, profound hemolytic anaemia, and hemodynamic instability. Serological investigations revealed AHTR from passive transfer of high titre anti\u2010A (256 for IgM and 8192 for IgG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This case highlights the potential risks associated with ABO\u2010mismatched transfusions, and the complexity associated with transfusing HSCT recipients and red cell transfusion recipients with dual populations of circulating red cells. The literature on minor ABO plasma incompatible transfusions, challenges in establishing local policies to limit the risks of AHTR and risk mitigation strategies are discussed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinicians must maintain a high level of suspicion for AHTR after ABO plasma incompatible platelet transfusions. Patients must be aware of the risks of AHTR, and early recognition and diagnosis of this complication may be lifesaving.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12938","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T05:25:14Z","timestamp":1668576314000},"page":"188-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Severe acute haemolytic transfusion reaction secondary to a plasma incompatible group B platelet transfusion"],"prefix":"10.1111","volume":"33","author":[{"given":"Marc","family":"Bienz","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akash","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Precision Diagnostics and Therapeutics Program Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"University of Toronto Quality in Utilization Education and Safety in Transfusion (QUEST) Research Program  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenette","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Precision Diagnostics and Therapeutics Program Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology and Haematology, Department of Medicine Sunnybrook Health Sciences Centre  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulia","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"},{"name":"Precision Diagnostics and Therapeutics Program Sunnybrook Health Sciences Centre  Toronto Ontario Canada"},{"name":"University of Toronto Quality in Utilization Education and Safety in Transfusion (QUEST) Research Program  Toronto Ontario 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