{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T08:40:08Z","timestamp":1774773608656,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objective<\/jats:title><jats:p>Blood donation is known to result in iron deficiency (ID), with a higher prevalence in females. There is little published data on the frequency of ID among blood donors in resource\u2010poor settings. We determined the prevalence of ID in blood donors in Uganda.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a descriptive cross\u2010sectional study at the Uganda Blood Transfusion Service, Kampala from December 2021 to February 2022. A sample of 500 whole blood donors was enrolled. The evaluation included demographic characteristics, donation history, nutritional history, complete blood count, and serum ferritin. The primary outcome was the proportion of donors with serum ferritin &lt;15\u2009\u03bcg\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median (IQR) serum ferritin was 25 (12\u201347) \u03bcg\/L and 89 (52\u2013133) \u03bcg\/L among female and male donors respectively. The prevalence of iron deficiency (serum ferritin &lt;15\u2009\u03bcg\/L) among donating individuals was 11.5% (8.7\u201314.9), while among low haemoglobin deferrals, 61.5% (50.9\u201371.1). The prevalence was high among females [33.0% (27.9\u201338.6)] compared with males [2.5% (1.0\u20135.8)], but even higher among females younger than 24\u2009years [35.4% (29.2\u201342.1)]. Factors associated with ID (adjusted odds ratio, 95% Cl, and significance) were; female donors (15.81, 5.17, 48.28, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and a high RDW (6.89, 2.99, 15.90, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). We found a moderate correlation between serum ferritin and RDW (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u22120.419 and \u22120.487 for males and females respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Iron deficiency is common among blood donors in Uganda, affecting mostly young female donors. Considerations to adopt evidence\u2010based strategies to prevent and manage ID among blood donors\u2013such as serum ferritin monitoring and iron supplementation are highly recommended.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12953","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T06:28:53Z","timestamp":1674800933000},"page":"213-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Iron deficiency in whole blood donors in a resource\u2010poor setting: A cross\u2010sectional study in <scp>Uganda<\/scp>"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5615-3925","authenticated-orcid":false,"given":"Aggrey","family":"Dhabangi","sequence":"first","affiliation":[{"name":"Child Health and Development Centre Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald","family":"Ssenyonga","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godfrey","family":"Siu","sequence":"additional","affiliation":[{"name":"Child Health and Development Centre Makerere University College of Health Sciences  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan Acana","family":"Elaborot","sequence":"additional","affiliation":[{"name":"Uganda Blood Transfusion Services  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Kyeyune","sequence":"additional","affiliation":[{"name":"Uganda Blood Transfusion Services  Kampala Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imelda","family":"Bates","sequence":"additional","affiliation":[{"name":"Liverpool School of Tropical Medicine and Hygiene  Liverpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,1,26]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"2","volume-title":"Global Status Report on Blood Safety and Availability 2016","author":"World Health Organization","year":"2017"},{"key":"e_1_2_10_3_1","first-page":"641","article-title":"Evaluation of iron stores in blood donors by serum ferritin","volume":"124","author":"Mittal R","year":"2006","journal-title":"Indian J Med Res"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12477"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15906"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12991"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60865-0"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.10.002"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0958-7578.2005.00590.x"},{"key":"e_1_2_10_10_1","first-page":"720","article-title":"Secondary school students: a safer blood donor population in an urban with high HIV prevalence in east Africa","volume":"71","author":"Jacobs B","year":"1994","journal-title":"East Afr Med J"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"113","article-title":"Anaemia, iron deficiency and iron deficiency anaemia among blood donors in Port Harcourt, Nigeria","volume":"8","author":"Jeremiah ZA","year":"2010","journal-title":"Blood Transfus"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12647"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03401.x"},{"key":"e_1_2_10_14_1","volume-title":"Iron Deficiency Anaemia: Assessment, Prevention and Control. 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