{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T02:12:24Z","timestamp":1781835144730,"version":"3.54.5"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To examine local patient safety events related to the administration of anti\u2010Rh(D) immune globin (RhIG) during pregnancy, and to follow\u2010up with targeted educational intervention to improve knowledge of this process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Administration RhIG is established treatment for the prevention of haemolytic disease of the foetus and newborn (HDFN). However, patient safety events in relation to its correct use continue to occur.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective audit of patient safety events related to RhIG administration during pregnancy was performed. Targeted educational intervention in the form of PowerPoint\u00ae presentation were given to nursing staff, laboratory staff and physicians and evaluated with pre\u2010 and post\u2010tests using multiple\u2010choice questions given immediately before and after the presentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>An annual incidence of 0.24% of patient safety events related to the administration of RhIG during pregnancy was found. These events were mostly in the preanalytical phase, for example mislabelled samples or samples for D\u2010rosette\/Kleihauer\u2013Betke testing drawn from the baby, not the mother. Using Bayesian analysis, the probability of positive effect for the targeted educational intervention was 100% with a median improved score of 29%. This was compared with a control group using standard curriculum education intervention based on the current curriculum for nursing, laboratory and medical students which showed a median improved score of only 4.4%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Administration of RhIG during pregnancy is a multistep process involving health care professionals of several disciplines providing opportunities to enhance the curriculum for nursing, laboratory and medical students and to ensure on\u2010going education.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12961","type":"journal-article","created":{"date-parts":[[2023,3,2]],"date-time":"2023-03-02T06:20:52Z","timestamp":1677738052000},"page":"244-253","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rh(D) immune globulin administration in pregnancy: Retrospective audit of patient safety events followed by targeted educational intervention with Bayesian analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Dima","family":"Hage","sequence":"first","affiliation":[{"name":"University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Pyra","sequence":"additional","affiliation":[{"name":"University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"McCudden","sequence":"additional","affiliation":[{"name":"University of Ottawa  Ottawa Ontario Canada"},{"name":"The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Eastern Ontario Regional Laboratory Association  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Padmore","sequence":"additional","affiliation":[{"name":"University of Ottawa  Ottawa Ontario Canada"},{"name":"The Ottawa Hospital  Ottawa Ontario Canada"},{"name":"Eastern Ontario Regional Laboratory Association  Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/110.3.281"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(88)70039-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1990.30490273444.x"},{"key":"e_1_2_11_5_1","first-page":"35","article-title":"Review of fetal and neonatal immune cytopenias","volume":"13","author":"Lewin S","year":"2015","journal-title":"Clin Adv Hematol Oncol"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2009.181172"},{"key":"e_1_2_11_7_1","first-page":"1245","article-title":"The pathogenesis and prevention of Rh immunization","volume":"97","author":"Zipursky A","year":"1967","journal-title":"Can Med Assoc J"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)34502-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.1971.tb04424.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.11.007"},{"key":"e_1_2_11_11_1","first-page":"8","article-title":"The role of antenatal immunoprophylaxis in the prevention of maternal\u2010foetal anti\u2010Rh(D) alloimmunisation","volume":"8","author":"Liumbruno GM","year":"2010","journal-title":"Blood Transfus"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12941"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/LMUNUP4FJTUX2GCD"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182742eba"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.88.2.209"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12175"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.21307\/immunohematology-2019-379"},{"key":"e_1_2_11_18_1","article-title":"Promoting professional behavior change in healthcare: what interventions work and why? 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