{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:52:05Z","timestamp":1790279525114,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T00:00:00Z","timestamp":1684540800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study evaluated the Human T\u2010lymphotropic virus (HTLV) screening policy impact on the HTLV seroprevalence from 2009 to 2018 as well as the differences between administrative districts in terms of prevalence distribution in Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Since February 1996, the Taiwan Blood Services Foundation (TBSF) had conducted HTLV screening of blood donors. The HTLV seroprevalence was 0.032% in 1999.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This cross\u2010sectional study included donors' data collected from blood donation centres across Taiwan from 2009 to 2018. Enzyme immunoassay and Western blot assay were used for screening and confirmation of HTLV infections. In this study, the researchers calculated the trends in the HTLV rates of first\u2010time and repeat donors across time as well as the HTLV prevalence distribution across the 22 administrative districts of Taiwan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Amongst 17\u2009977\u2009429 employed blood donations, 739 HTLV\u2010seropositive donations (4.11 per 100\u2009000 donations) were identified. The HTLV\u2010positive donors were aged between 17 and 64\u2009years, with a median age of 49\u2009years. The overall seropositivity rates of first\u2010time and repeat donors were 34.36\/100\u2009000 and 1.27\/100\u2009000. HTLV seroprevalence in first\u2010time blood donors significantly decreased by 57% (crude odds ratio [95% confidence interval] (crude OR [95% CI])\u2009=\u20090.43 [0.28\u20130.64]) within 10\u2009years. A slight decline was also identified in repeat donors (crude OR [95% CI]\u2009=\u20090.73 [0.4\u20131.32]). Donors from different districts showed significantly varied prevalence. Most districts with high prevalence are situated in eastern Taiwan, for both donation types. Older blood donors were more likely to be infected with HTLV than younger ones in first time and repeat donors. Middle age donors (50\u201365\u2009years) had an 18.47\u201339.65 greater risk than those aged &lt;20\u2009years. Significant higher risk of female was observed in both donation types. Amongst different age groups, first\u2010time female donors increase 1.31\u20131.88 times infection risk and female in repeat donor group had 1.55\u20133.43 times greater risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Over years of implementation of the HTLV blood donor screening policy by the TBSF, the HTLV seroprevalence of first\u2010time donors has decreased consistently. Moreover, the HTLV seroprevalence of repeat donors has dropped considerably. This implies that the screening policy provides continued benefit. Females and older blood donors were more likely infected with HTLV than males and younger blood donors. The influence of age on infection was greater amongst first\u2010time donors than amongst repeat donors. Therefore, appropriate measures should be taken to ensure public safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12979","type":"journal-article","created":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T10:04:57Z","timestamp":1684577097000},"page":"320-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Trend in seroprevalence of <scp>HTLV<\/scp>\u20101\/2 in Taiwanese blood donors\u2014A 10\u2010year follow\u2010up"],"prefix":"10.1111","volume":"33","author":[{"given":"Yu\u2010Han","family":"Lee","sequence":"first","affiliation":[{"name":"Kaohsiung Blood Center Taiwan Blood Services Foundation  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Te","family":"Lu","sequence":"additional","affiliation":[{"name":"Kaohsiung Blood Center Taiwan Blood Services Foundation  Kaohsiung 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