{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T00:04:01Z","timestamp":1780617841226,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T00:00:00Z","timestamp":1686096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Although no case of COVID\u201019 transmission through transfusion has been reported, blood transfusion service (BTS) continues to implement pre\u2010donation and post\u2010donation measures to minimise the risk. In year 2022, when local healthcare system was badly impacted by a major outbreak, it opened an opportunity to re\u2010examine the viraemia risk in these asymptomatic donors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Records were retrieved from blood donors who reported COVID\u201019 after donation and follow\u2010up was also made for recipients who received their blood. Blood samples at donation were tested for SARS\u2010CoV\u20102 viraemia by single\u2010tube nested real\u2010time RT\u2010PCR assay designed to detect most SARS\u2010CoV\u20102 variants including the prevailing delta and omicron variants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 1 January to 15 August 2022, the city with 7.4\u2009M inhabitants recorded 1\u2009187\u2009844 COVID\u201019 positive cases and 125\u2009936 successful blood donations were received. 781 donors reported to the BTS after donation with 701 being COVID\u201019 related (including close contact and symptoms respiratory tract infection). 525 COVID\u201019 were positive at the time of call back or follow\u2010up.<\/jats:p><jats:p>Of the 701 donations, they were processed into 1480 components with 1073 discarded upon donors' call back. For remaining 407 components, no recipient was found to have adverse event or COVID\u201019 positive. 510 samples from the above 525 COVID\u201019 positive donors were available and all tested negative for SARS\u2010CoV\u20102 RNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>With the negative SARS\u2010CoV\u20102 RNA in blood donation samples and follow up data in transfusion recipients, the risk of transfusion transmitted COVID\u201019 appears negligible. However, current measures remains important in securing blood safety with ongoing surveillance of their effectiveness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12981","type":"journal-article","created":{"date-parts":[[2023,6,8]],"date-time":"2023-06-08T02:55:32Z","timestamp":1686192932000},"page":"315-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Re\u2010examine the transfusion transmitted risk of <scp>SARS\u2010CoV<\/scp>\u20102 virus during a major <scp>COVID<\/scp>\u201019 outbreak in 2022"],"prefix":"10.1111","volume":"33","author":[{"given":"S. C.","family":"Ng","sequence":"first","affiliation":[{"name":"Hong Kong Red Cross Blood Transfusion Service  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. W. H.","family":"Chu","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. M.","family":"Chan","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. C. Y.","family":"Yip","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. H.","family":"Leung","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"So","sequence":"additional","affiliation":[{"name":"Hong Kong Red Cross Blood Transfusion Service  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. N. S.","family":"Leung","sequence":"additional","affiliation":[{"name":"Hong Kong Red Cross Blood Transfusion Service  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. K. W.","family":"To","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine The University of Hong Kong  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Hong Kong Red Cross Blood Transfusion Service  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/voxs.12558"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2020.102961"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.11.03053"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004844"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30186-1"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12931"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15841"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15943"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2607.200839"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tracli.2020.10.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI159876"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008230"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12925"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12724"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12747"},{"key":"e_1_2_8_17_1","article-title":"Development and evaluation of novel and highly sensitive single\u2010tube nested real\u2010time RT\u2010PCR assays for SARS\u2010CoV\u20102 detection","volume":"21","author":"Yip CC","year":"2020","journal-title":"Int J Mol Sci"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12981","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T15:42:02Z","timestamp":1692286922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,7]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/tme.12981"],"URL":"https:\/\/doi.org\/10.1111\/tme.12981","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,7]]},"assertion":[{"value":"2022-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}