{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:16:24Z","timestamp":1718410584704},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Brazil has a high prevalence of arboviruses, especially Dengue (DENV), Zika (ZKV), and Chikungunya (CHKV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To study the risk of DENV, ZKV, and CHKV transmission by blood components in the haematopoietic stem cell transplantation (HSCT) population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective cohort of HSCT recipients and donors performed at the Hospital das Clinicas da FMUSP, S\u00e3o Paulo\u2010Brazil. Patients were evaluated by serology and RT\u2010PCR for DENV, ZKV, and CHKV pre\u2010transplantation and once a week until neutrophil grafting. In positive cases (positive RT\u2010PCR and\/or serology conversion), an investigation was carried out on the blood components that the patient received to evaluate the possibility of it being transfusion transmitted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 93 patients were included during the study period. The mean age was 52\u2009years with a predominance of males (56.9%). We considered five (5.3%) DENV cases positive by seroconversion in our study. One patient had IgM seroconversion and the other four presented IgG seroconversion to DENV. In the investigation of the blood components, 145 individual samples were analysed. None of the investigated blood components showed a positive RT\u2010PCR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed a low prevalence of DENV, ZKV, and CHKV in HSCT donors and recipients by serology and RT\u2010PCR, and no case of blood transfusion transmission by RT\u2010PCR.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.12987","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T07:54:39Z","timestamp":1690876479000},"page":"403-408","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Dengue, Zika virus, and Chikungunya virus transmission by blood components in recipients of haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"33","author":[{"given":"Fernando Nivaldo","family":"de Oliveira","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica (LIM\u201049), Instituto de Medicina Tropical, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Departamento de Biologia Molecular Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue\/Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzete Cleusa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica em Patog\u00eanese e Terapia dirigida em Onco\u2010Imuno\u2010Hematologia (LIM\u201031), Departamento de Hematologia, Hospital das Clinicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Shoko","family":"Nishiya","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica em Patog\u00eanese e Terapia dirigida em Onco\u2010Imuno\u2010Hematologia (LIM\u201031), Departamento de Hematologia, Hospital das Clinicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo","family":"Mendrone\u2010Junior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica em Patog\u00eanese e Terapia dirigida em Onco\u2010Imuno\u2010Hematologia (LIM\u201031), Departamento de Hematologia, Hospital das Clinicas (HCFMUSP), Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjorie Vieira","family":"Batista","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica (LIM\u201049), Instituto de Medicina Tropical, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Departamento de Biologia Molecular Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue\/Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanderson","family":"Rocha","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Unit Hospital das Clinicas da Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Figueiredo","family":"Costa","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Investiga\u00e7\u00e3o M\u00e9dica (LIM\u201049), Instituto de Medicina Tropical, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Departamento de Biologia Molecular Funda\u00e7\u00e3o Pr\u00f3\u2010Sangue\/Hemocentro de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Departamento de Mol\u00e9stias Infecciosas e Parasit\u00e1rias, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5811\/westjem.2016.9.30904"},{"key":"e_1_2_9_3_1","unstructured":"Boletim Epidemiol\u00f3gico Secretaria de Vigil\u00e2ncia em Sa\u00fade Minist\u00e9rio da Sa\u00fade 2018: volume 49 n\u00famero 51."},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14322"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12944"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.17-0843"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.htct.2018.01.011"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2405.171747"},{"issue":"4","key":"e_1_2_9_9_1","article-title":"Prolonged viremia in dengue virus infection in hematopoietic stem cell transplant recipients and patients with hematological malignancies","volume":"19","author":"Pereira BBS","year":"2017","journal-title":"Transpl Infect Dis"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213793"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmaid.2019.03.001"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2017.152"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2017.09.001"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00442-17"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2016.21.50.30426"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15771"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.12987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,14]],"date-time":"2024-06-14T11:20:36Z","timestamp":1718364036000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.12987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1111\/tme.12987"],"URL":"https:\/\/doi.org\/10.1111\/tme.12987","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2022-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}