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Other blood services have a variety of policies in place to ensure the virological safety of blood components, ranging from an indefinite ban on MSM, to a defined period of exclusion, or to an individualised risk assessment that is not based on gender or sexual orientation. Justification of these policies should be based on scientific evidence including assessment of lengths of virological window periods, infectious disease epidemiology within donor populations and donation screening assay sensitivities. Developments in molecular technology and assays which can detect both antibodies and antigens in the very early stages of infection have significantly reduced the risk in most developed countries. However, the increasing usage of pre\u2010exposure prophylaxis (PrEP) to prevent acquisition of HIV infection after possible high\u2010risk sexual contact within the UK blood donor population has been recently noted. It has brought with it new diagnostic challenges within blood screening, notably possible non\u2010detection of HIV RNA and serological markers following PrEP use despite potential infectivity. The use of other testing strategies such as detection of HIV DNA and screening for non\u2010declared PrEP usage should be investigated further.<\/jats:p>","DOI":"10.1111\/tme.12993","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T10:43:46Z","timestamp":1693910626000},"page":"372-378","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Virological safety of the <scp>UK<\/scp> blood supply in the era of individual risk assessments and <scp>HIV PrEP<\/scp>"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0766-8860","authenticated-orcid":false,"given":"Victoria","family":"Maddox","sequence":"first","affiliation":[{"name":"Microbiology Services NHS Blood and Transplant  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela","family":"Vallely","sequence":"additional","affiliation":[{"name":"Division of Evolution, Infection and Genomics Science, Faculty of Biology, Medicine and Health University of Manchester  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan R.","family":"Brailsford","sequence":"additional","affiliation":[{"name":"Microbiology Services NHS Blood and Transplant  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-4190","authenticated-orcid":false,"given":"Heli","family":"Harvala","sequence":"additional","affiliation":[{"name":"Microbiology Services NHS Blood and Transplant  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423\u20100410.2010.01426.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537\u20102995.2010.02996.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17127"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14102263"},{"key":"e_1_2_10_6_1","unstructured":"Serious Hazards of Transfusion (SHOT) Steering Group.SHOT report.2021."},{"key":"e_1_2_10_7_1","first-page":"250","article-title":"Pneumocystis pneumonia\u2014Los Angeles","volume":"30","author":"CDC","year":"1981","journal-title":"MMWR"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.290.6470.749"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423\u20100410.1988.tb01609.x"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d5604"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.13033"},{"key":"e_1_2_10_12_1","unstructured":"Advisory Committee on the Safety of Blood.Tissues and Organs (SaBTO) Donor Selection Criteria Report.2017."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12576"},{"key":"e_1_2_10_14_1","unstructured":"For the Assessment of Individualised Risk (FAIR) Steering Group.FAIR steering commitee report.2021."},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12933"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.09.016"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2450\/2017.0109\u201016"},{"key":"e_1_2_10_18_1","unstructured":"NHS Blood and Transplant.Blood donor selection policy: more people now are able to give blood (internet). 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