{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T18:45:50Z","timestamp":1787683550409,"version":"build-2784847793"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Serum eye drops (SED) are used to treat ocular surface disease. Reactions to SED are poorly documented.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present our experience of self\u2010reported reactions in New Zealand to SED (25%; autologous, allogeneic, or both) between 2003 and 2023, and a focused review of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 1067 patients received SED treatment (562 autologous, 318 allogeneic, and 187 both). Three (0.5% of those treated with allogeneic SED) reported reactions. All appeared to be allergic. All were associated with allogeneic SED. We have information on two patients: one had an eye reaction; in the other, the gastrointestinal tract was involved. The literature contains few reports of reactions to SED. They have involved both autologous and allogeneic SED, and various SED concentrations. None appears to have been severe. Notably, no eye or systemic infections have been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Information on the types and frequencies of reactions to SED is poor. This may be due to: serum being less likely to cause reactions; eyes being resistant to reactions; reactions being rare, and insufficient use of SED having occurred; under\u2010reporting related to SED use at home and reactions being mild. More robust monitoring for reactions to SED is needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13017","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T10:09:24Z","timestamp":1699610964000},"page":"61-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Reactions to serum eye drops\u2014New Zealand experience and review of the literature"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4634-3792","authenticated-orcid":false,"given":"Krishna G.","family":"Badami","sequence":"first","affiliation":[{"name":"New Zealand Blood Service  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malcolm","family":"McKellar","sequence":"additional","affiliation":[{"name":"Dr Malcolm McKellar Ltd  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,10]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"1","article-title":"The Royal College of Ophthalmologists guidelines on serum eye drops for the treatment of severe ocular surface disease: full report","volume":"17","author":"Rauz S","year":"2017","journal-title":"Eye"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-301668"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6703079"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2012.0002"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/521315"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-014-2599-1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.12386"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000271"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/826970"},{"key":"e_1_2_9_11_1","doi-asserted-by":"crossref","unstructured":"LekhanontK JongkhajornpongP AnothaisintaweeT ChuckpaiwongV.Undiluted Serum Eye Drops for the Treatment of Persistent Corneal Epitheilal Defects; 2016 srep38143 (1).pdf. Accessed May 17 2023.","DOI":"10.1038\/srep38143"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ejhpharm-2018-001527"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01560-8"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aos.14788"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12502"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2017.07.023"},{"key":"e_1_2_9_17_1","unstructured":"Centers for Disease Control and Prevention.Outbreak of Extensively Drug\u2010resistant Pseudomonas aeruginosa Associated with Artificial Tears. Accessed May 17 2023.https:\/\/www.cdc.gov\/hai\/outbreaks\/CRPA-artificial-tears.html"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14102176"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.19-28632"},{"key":"e_1_2_9_20_1","volume-title":"Transfusion Reactions","author":"Fontaine MJ","year":"2021"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2008.03716.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11133643"},{"key":"e_1_2_9_23_1","first-page":"189","article-title":"Dangerous liaison: sexually transmitted allergic reaction to Brazil nuts","volume":"17","author":"Bansal AS","year":"2007","journal-title":"J Investig Allergol Clin Immunol"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12984"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S118409"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.13017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T05:41:53Z","timestamp":1710740513000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.13017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,10]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/tme.13017"],"URL":"https:\/\/doi.org\/10.1111\/tme.13017","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,10]]},"assertion":[{"value":"2023-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}