{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T23:00:27Z","timestamp":1772060427132,"version":"3.50.1"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T00:00:00Z","timestamp":1704758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our objective was to compare the measurement of residual white blood cell (rWBC) and residual red blood cell (rRBC) counts in blood products using the XN Blood Bank mode and the laboratory standard operating procedures for manual counts. In addition, to compare the whole blood complete blood count (CBC) values of blood donors and the quality of blood products using the Sysmex XN analyser versus the XS\u20101000i analyser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>For blood donors, 190 samples from blood or apheresis donors were analysed on both the Sysmex XS\u20101000i and XN\u20101000 analysers and the mean values of six CBC parameters were compared: the white blood cell count (WBC), the red blood cell count (RBC), haemoglobin (HGB), haematocrit (HCT), the mean corpuscular volume (MCV), the platelet count (PLT). For blood products, 164 samples were collected: 13 Plasma products \u2013 whole blood, 9 Plasma products \u2013 apheresis, 36 RBC concentrates \u2013 whole blood, 30 PLT concentrates \u2013 buffy coats, 36 PLT concentrates \u2013 buffy coats \u2013 pooled and 55 PLT concentrates \u2013 apheresis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All CBC parameters of the blood donors tested showed similar performance, with excellent correlation coefficients (<jats:italic>r<\/jats:italic>) ranging from 0.821 to 0.995. The majority of the blood products did not have a quantifiable number of residual cells, meaning the number of rWBC and rRBC, if present, was below the limit of quantitation (LoQ) of the different methods. rWBC were detected by Blood Bank mode in Plasma products \u2013 whole blood with a mean rWBC of 0.012\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L and in PLT concentrates \u2013 buffy coats with a mean rWBC of 0.19\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L. The correlation coefficient in both analysers for all three parameters (HGB, HCT, RBC) in RBC concentrates \u2013 whole blood was excellent, ranging from 0.95 to 0.99. For platelet count, <jats:italic>r<\/jats:italic> ranged from 0.98 to 0.99.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The XN\u2010Series analyser, equipped with a Blood Bank mode, demonstrated reliable performance when used for blood donor evaluation, rWBC enumeration and measurement of end blood products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13028","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T10:39:54Z","timestamp":1704796794000},"page":"30-38","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Validation of the Sysmex <scp>XN<\/scp> analyser and Blood Bank mode for the quality and safety of donor blood and transfusion products"],"prefix":"10.1111","volume":"34","author":[{"given":"Ondrej","family":"Valina","sequence":"first","affiliation":[{"name":"Haematology Department Sysmex Europe SE  Norderstedt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Vankova","sequence":"additional","affiliation":[{"name":"Apheresis and Transfusion Departments Institute of Haematology and Blood Transfusion  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Mintzas","sequence":"additional","affiliation":[{"name":"Haematology Department Sysmex Europe SE  Norderstedt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klara","family":"Knappova","sequence":"additional","affiliation":[{"name":"Apheresis and Transfusion Departments Institute of Haematology and Blood Transfusion  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zdenka","family":"Gasova","sequence":"additional","affiliation":[{"name":"Apheresis and Transfusion Departments Institute of Haematology and Blood Transfusion  Prague Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,9]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Guidance for Industry: Pre\u2010Storage Leukocyte Reduction of Whole Blood and Blood Components Intended for Transfusion","author":"US Food and Drug Administration Center for Biologics Evaluation and Research","year":"2012"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1992.32692367203.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0887-7963(97)80009-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40050513.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1994.tb00272.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15606"},{"key":"e_1_2_10_8_1","unstructured":"Quality assurance in haematology. WHO Document LAB\/98.41998."},{"key":"e_1_2_10_9_1","first-page":"1","article-title":"Performance comparison of two Sysmex hematology analyzers: the XN\u2010550 and the XS\u20101000i","volume":"28","author":"Zhang QY","year":"2018","journal-title":"Sysmex J Int"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2008.01930.x"},{"key":"e_1_2_10_11_1","first-page":"18","article-title":"Evaluation of the Blood Bank mode software of Sysmex XN\u20101000 Hematology Analyzer for counting residual red blood cells and platelets in platelet concentrates, and residual white blood cells in leukocyte\u2010reduced whole blood","volume":"31","author":"Arisawa F","year":"2021","journal-title":"Sysmex J Int"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16196"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.13028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T05:41:49Z","timestamp":1710740509000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.13028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,9]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1111\/tme.13028"],"URL":"https:\/\/doi.org\/10.1111\/tme.13028","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,9]]},"assertion":[{"value":"2023-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}