{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:04:33Z","timestamp":1747188273816,"version":"3.40.5"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T00:00:00Z","timestamp":1705968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Science and Technology Department of Sichuan Province","doi-asserted-by":"publisher","award":["2020YFH0024"],"award-info":[{"award-number":["2020YFH0024"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis B virus (HBV) reactivity in individual immunologic and nucleic acid tests (NAT) tests does not represent the true infectious status of the blood donor. This study discusses the use of confirmatory tests to determine when deferral of blood donors is appropriate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>HBsAg or HBV NAT reactive samples were confirmed via a neutralisation test. All the HBsAg reactive but neutralisation test negative samples were subjected to further anti\u2010HBc testing. The receiver operating characteristic curve was used to obtain the best threshold value using signal\u2010to\u2010cut\u2010off ratios of two HBsAg enzyme\u2010linked immunosorbent assay reagents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 780 HBV reactive samples collected, there were 467 HBsAg reactive but HBV DNA negative samples, of which 65 (13.92%) and 402 (86.08%) were neutralisation test positive and negative, respectively. Of the 402, 91 samples (30% of tested samples) were anti\u2010HBc reactive. HBV DNA positive specimens negative by virus neutralisation were &gt;80% HBcAg positive. A screening strategy was proposed for Chinese blood collection agencies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These findings suggest that adopting a screening algorithm for deferring HBV reactive blood donors based on HBsAg and NAT testing followed with HBsAg S\/CO consideration and HBcAg testing can be both safe and feasible in China.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13030","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T11:39:22Z","timestamp":1706009962000},"page":"136-141","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Suggested blood donor deferral strategy regarding hepatitis B infections in China"],"prefix":"10.1111","volume":"34","author":[{"given":"Ling","family":"Li","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion, The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University  Chengdu People's Republic of China"},{"name":"School of Public Health Anhui Medical University  Hefei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Blood Screening Laboratory Beijing Red Cross Blood Center  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Guo","sequence":"additional","affiliation":[{"name":"Medical Affairs Department Beijing Red Cross Blood Center  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"He","sequence":"additional","affiliation":[{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Chengdu People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengmin","family":"Liu","sequence":"additional","affiliation":[{"name":"Blood Screening Laboratory Beijing Red Cross Blood Center  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianqian","family":"Qin","sequence":"additional","affiliation":[{"name":"Blood Screening Laboratory Beijing Red Cross Blood Center  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Blood Screening Laboratory Beijing Red Cross Blood Center  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Wu","sequence":"additional","affiliation":[{"name":"Blood Screening Laboratory Beijing Red Cross Blood Center  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqin","family":"Huang","sequence":"additional","affiliation":[{"name":"Blood Components Procession Department Shenzhen Blood Center  Shenzhen People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Ge","sequence":"additional","affiliation":[{"name":"Blood Screening Laboratory Beijing Red Cross Blood Center  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8173-9656","authenticated-orcid":false,"given":"Zhong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health Anhui Medical University  Hefei People's Republic of China"},{"name":"Clinical Transfusion Research Center Institute of Blood Transfusion, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Chengdu People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,23]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Food and Drug Administration.Use of nucleic acid tests on pooled and individual samples from donors of whole blood and blood components including source plasma to reduce the risk of transmission of hepatitis B virus. Guidance for Industry.2011. Accessed October 5 2022.https:\/\/www.fda.gov\/media\/124225\/download"},{"key":"e_1_2_12_3_1","unstructured":"Technical operation procedures of blood center (version 2019).National Health Medical Letter No. 98.2019."},{"key":"e_1_2_12_4_1","unstructured":"World Health Organization.Screening donated blood for transfusion\u2010transmissible infections: recommendations.2009. Accessed October 5 2022.https:\/\/apps.who.int\/iris\/handle\/10665\/44202"},{"issue":"3","key":"e_1_2_12_5_1","first-page":"268","article-title":"Confirmation of HBV infection and evaluation of HBV nucleic acid detection efficiency in HBsAg\u2010negative blood donors in Dalian blood center","volume":"27","author":"Wanxin A","year":"2014","journal-title":"Chin J Blood Transf"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i12.1543"},{"issue":"9","key":"e_1_2_12_7_1","first-page":"993","article-title":"Serological and nucleic acid quantitative detection of HBsAg\u2212\/ HBVDNA+ blood donors","volume":"31","author":"Ni Xiuwen X","year":"2018","journal-title":"Chin J Blood Transf"},{"issue":"1","key":"e_1_2_12_8_1","first-page":"53","article-title":"Follow\u2010up investigation of 31 blood donors positive for hepatitis B virus nucleic acid test","volume":"19","author":"Haiying S","year":"2017","journal-title":"Clin Blood Transf Test"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.13030","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T05:16:50Z","timestamp":1712294210000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.13030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,23]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1111\/tme.13030"],"URL":"https:\/\/doi.org\/10.1111\/tme.13030","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"type":"print","value":"0958-7578"},{"type":"electronic","value":"1365-3148"}],"subject":[],"published":{"date-parts":[[2024,1,23]]},"assertion":[{"value":"2023-04-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}