{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T02:04:39Z","timestamp":1747188279183,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T00:00:00Z","timestamp":1724630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To propose a rational basis for donor testing in cases of suspected antibody\u2010mediated transfusion\u2010related lung injury (AMT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Anti\u2010leukocyte antibodies in donated blood are established causes of transfusion\u2010related lung injury (TRALI). However, the question of whether to test donors for antibodies is not identical to whether the case meets definition criteria for TRALI. There is a balance between the potential benefits of testing and the costs of donor deferral and investigation. We propose that a decision\u2010making process based on optimising the balance between risk and benefit requires a subjective choice of the relative value of different outcomes of testing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have developed a formal decision model to illustrate how these choices affect testing decisions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using a Bayesian probability model, we show that the diagnostic benefit and TRALI prevention benefit of testing donors have a complex interrelationship with the number of implicated donors and clinical suspicion of antibody\u2010mediated TRALI (AMT) and that rational testing choices vary according to value assigned to outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The challenges to the use of a formal decision model for clinical testing are discussed and conclude that a formal model is a useful consensus\u2010building tool for improving consistency and openness in decision making.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13073","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T23:45:10Z","timestamp":1724715910000},"page":"405-412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Construction of a decision model for donor testing in cases of suspected antibody\u2010mediated transfusion\u2010related\u2010acute\u2010lung\u2010injury"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9396-4683","authenticated-orcid":false,"given":"Tom","family":"Latham","sequence":"first","affiliation":[{"name":"NHS Blood and Transplant  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Bentley","sequence":"additional","affiliation":[{"name":"Manchester Academic Health Sciences Centre University of Manchester  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharran","family":"Grey","sequence":"additional","affiliation":[{"name":"Blackpool Teaching Hospitals NHS Foundation Trusts  Blackpool UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Puneet","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Mersey and West Lancashire Hospitals NHS Trust  Ormskirk"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0669-2485","authenticated-orcid":false,"given":"Peter J.","family":"Davis","sequence":"additional","affiliation":[{"name":"University Hospitals Bristol and Weston NHS Trust  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Clarkson","sequence":"additional","affiliation":[{"name":"NHS Blood and transplant  Barnsley UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Poles","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shruthi","family":"Narayan","sequence":"additional","affiliation":[{"name":"NHS Blood and Transplant  Manchester UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,8,26]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_8_2_1","DOI":"10.1111\/bjh.13459"},{"doi-asserted-by":"publisher","key":"e_1_2_8_3_1","DOI":"10.1111\/trf.15311"},{"doi-asserted-by":"publisher","key":"e_1_2_8_4_1","DOI":"10.1111\/j.0041-1132.2004.04347.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_5_1","DOI":"10.1111\/j.1423-0410.2011.01570.x"},{"doi-asserted-by":"publisher","key":"e_1_2_8_6_1","DOI":"10.1111\/j.1537-2995.2011.03120.x"},{"unstructured":"NarayanS(Ed) PolesD et al.On behalf of the Serious Hazards of Transfusion (SHOT) Steering Group. The 2022 Annual SHOT Report (2023).https:\/\/doi.org\/10.57911\/WZ85-3885.","key":"e_1_2_8_7_1"},{"doi-asserted-by":"publisher","key":"e_1_2_8_8_1","DOI":"10.1016\/j.bjae.2020.03.002"},{"doi-asserted-by":"publisher","key":"e_1_2_8_9_1","DOI":"10.4103\/picr.PICR_41_18"},{"volume-title":"Theory of Games and Economic Behavior","year":"1953","author":"Neumann J","key":"e_1_2_8_10_1"},{"key":"e_1_2_8_11_1","first-page":"227","article-title":"Reporting transfusion\u2010related acute lung injury by clinical and preclinical disciplines","volume":"16","author":"Peters AL","year":"2018","journal-title":"Blood Transfus"},{"doi-asserted-by":"publisher","key":"e_1_2_8_12_1","DOI":"10.1513\/AnnalsATS.202108-963CME"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.13073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T01:35:33Z","timestamp":1728610533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.13073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,26]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["10.1111\/tme.13073"],"URL":"https:\/\/doi.org\/10.1111\/tme.13073","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"type":"print","value":"0958-7578"},{"type":"electronic","value":"1365-3148"}],"subject":[],"published":{"date-parts":[[2024,8,26]]},"assertion":[{"value":"2024-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}