{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T12:40:55Z","timestamp":1783687255530,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,8,25]],"date-time":"2024-08-25T00:00:00Z","timestamp":1724544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Objectives<\/jats:title><jats:p>Iron deficiency (ID) poses a prevalent concern among blood donors, especially impacting young donors, premenopausal females and frequent donors. In alignment with recommendations to address ID, routine ferritin testing was implemented in a hospital\u2010based donor centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Data set, encompassing 26\u2009164 ferritin values from 16\u2009464 blood donors over 33\u2009months, were analysed retrospectively. Ferritin levels were assessed concerning donor characteristics such as sex, age, ethnicity and donation frequency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ferritin testing revealed age, sex and ethnicity variations, emphasising the heightened risk of ID in young females meeting all donation criteria under 23\u2009year of age who demonstrated the lowest mean baseline ferritin (41% [CI: 34%\u201348%]\u2009&lt;\u200926\u2009ng\/mL; 20% [CI: 14%\u201325%]\u2009&lt;\u200915\u2009ng\/mL). Postmenopausal females exhibited ferritin levels similar to similarly aged males. Irrespective of sex, donors showcased mean ferritin recovery within 6\u2009months. Analysis of ferritin recovery post\u2010donation showed a five\u2010fold increase in risk (compared with first visit) of ID when donors return at a 2\u2010month interval. \u2018Regular\u2019 donors (\u226510 visits) approach a median steady ferritin level (~30\u201335\u2009ng\/mL) by the sixth visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As reliance on regular blood donors increases, donation policies must strike a balance between blood centre resources and the risks posed to both regular and at\u2010risk donors. Frequent blood donation led to donors attaining a mean steady state ferritin level above the threshold for ID. At\u2010risk groups, particularly premenopausal females, were several times more likely to experience ID after donation but demonstrated recovery rates similar to their group's baseline levels. This valuable information informed the development of new donor deferral policies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13081","type":"journal-article","created":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T04:06:08Z","timestamp":1724645168000},"page":"491-498","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating utility of routine ferritin testing in blood donors: A hospital\u2010based blood donor centre experience"],"prefix":"10.1111","volume":"34","author":[{"given":"Philip","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Pathology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hesamedin","family":"Hakimjavadi","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikar","family":"Chamala","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Southern California  Los Angeles California USA"},{"name":"Department of Pathology &amp; Laboratory Medicine Children's Hospital Los Angeles  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7885-635X","authenticated-orcid":false,"given":"Gagan","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Southern California  Los Angeles California USA"},{"name":"Department of Pathology &amp; Laboratory Medicine Children's Hospital Los Angeles  Los Angeles California USA"},{"name":"University of California Irvine School of Medicine  Irvine California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03401.x"},{"key":"e_1_2_11_3_1","unstructured":"Updated strategies to limit or prevent iron deficiency in blood donors. AABB Association Bulletin #17\u201002. Accessed March 1 2024.https:\/\/www.aabb.org\/docs\/default\u2010source\/default\u2010document\u2010library\/resources\/association\u2010bulletins\/ab17\u201002.pdf"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13793"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.119"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13659"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13469"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31928-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13663"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16278"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.426"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499768"},{"key":"e_1_2_11_13_1","first-page":"167","article-title":"The effect of repeated blood donations on the iron status of male Saudi blood donors","volume":"9","author":"Abdullah SM","year":"2011","journal-title":"Blood Transfus"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232125"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab035"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.02649.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2011.03353.x"},{"key":"e_1_2_11_18_1","first-page":"357","article-title":"Iron deficiency prevalence in blood donors: a systematic review, 2001\u20102011","volume":"86","author":"Mantilla\u2010Guti\u00e9rrez CY","year":"2012","journal-title":"Rev Esp Salud Publica"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15906"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13956"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOH.0b013e32836589f2"},{"key":"e_1_2_11_22_1","unstructured":"AABB.Donor iron deficiency risk\u2010based decision\u2010making assessment report. Report of the Ad Hoc Iron\u2010Deficiency Working Group. 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