{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T08:34:41Z","timestamp":1772094881792,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Worldwide, there has been a worrying increase in the prevalence of syphilis. Blood banks have a major role in monitoring the trend of these events, despite the bias due to the altruistic donation strategy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To determine the seroprevalence of syphilis and analyse its association with defined risk factors among blood donors at the regional blood center at Hospital Prof. Dr. J. P. Garrahan, period 2016\u20132022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Donor screening was performed with treponemal and non\u2010treponemal tests to determine the prevalence of active and past syphilis. Sociodemographic characteristics of donors were analysed and the association with potential risk factors was assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 72\u2009874 donations were processed during the study period. The overall prevalence of specific anti\u2010<jats:italic>Treponema pallidum<\/jats:italic> antibodies was 0.69% (95% CI\u2009=\u20090.63\u20130.75). Active syphilis seroprevalence was 0.30% (95% CI\u2009=\u20090.25\u20130.33). Not active syphilis seroprevalence was 0.39% (95% CI\u2009=\u20090.35\u20130.44). Anti\u2010<jats:italic>T. pallidum<\/jats:italic> seroprevalence among first\u2010time donations was 1.26% (95% CI\u2009=\u20091.14\u20131.38) while in repeat donations it was 0.16% (95% CI\u2009=\u20090.12\u20130.21). In univariate analysis, we found an association between syphilis and having a history of any sexually transmitted infection (OR: 5.09, 95% CI\u2009=\u20092.20\u201311.70, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) and being first\u2010time donors (OR: 3.48, 95% CI\u2009=\u20091.70\u20137.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the overall prevalence of syphilis is 0.69%, among repeat donors prevalence as low as 0.16% was found. This demonstrates the need to maintain and improve screening strategies and promotion of voluntary, altruistic and repeat donation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13121","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T03:29:04Z","timestamp":1737689344000},"page":"184-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Syphilis in a blood bank in <scp>A<\/scp>rgentina: Prevalence trends and risk factors"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6637-6016","authenticated-orcid":false,"given":"Ana","family":"Rios Trevisan","sequence":"first","affiliation":[{"name":"Hospital de Pediatr\u00eda Hospital de Pediatr\u00eda Prof. Dr. Juan P. Garrahan  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Fernandez","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda Hospital de Pediatr\u00eda Prof. Dr. Juan P. Garrahan  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"Puppo","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda Hospital de Pediatr\u00eda Prof. Dr. Juan P. Garrahan  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirta Cristina","family":"Remesar","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda Hospital de Pediatr\u00eda Prof. Dr. Juan P. Garrahan  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Macarena","family":"Roel","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda Hospital de Pediatr\u00eda Prof. Dr. Juan P. Garrahan  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvina","family":"Kuperman","sequence":"additional","affiliation":[{"name":"Hospital de Pediatr\u00eda Hospital de Pediatr\u00eda Prof. Dr. Juan P. Garrahan  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"\u201cS\u00edfilis OPS\/OMS\u201d.https:\/\/www.paho.org\/es\/temas\/sifilis"},{"key":"e_1_2_13_3_1","volume-title":"Sexually Transmitted Disease Surveillance 2018","author":"Centers for Disease Control and Prevention","year":"2019"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(04)01061-8"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/315209"},{"key":"e_1_2_13_6_1","unstructured":"Direcci\u00f3n de Respuesta al VIH ITS Hepatitis Virales y Tuberculosis Ministerio de Salud de la Naci\u00f3n Argentina: Bolet\u00edn N\u00b0 38 Respuesta al VIH y las ITS en la Argentina pp. 16\u201319.2021https:\/\/bancos.salud.gob.ar\/recurso\/boletin-ndeg-38-respuesta-al-vih-y-las-its-en-la-argentina"},{"key":"e_1_2_13_7_1","unstructured":"Direcci\u00f3n Nacional de Epidemiolog\u00eda e Informaci\u00f3n Estrat\u00e9gica Ministerio de Salud de la Naci\u00f3n Argentina: Bolet\u00edn Epidemiol\u00f3gico Nacional N\u00b0679 SE 46\/2023.2023https:\/\/www.argentina.gob.ar\/salud\/boletin-epidemiologico-nacional\/boletines-2023"},{"key":"e_1_2_13_8_1","unstructured":"Direcci\u00f3n Nacional de Epidemiolog\u00eda y An\u00e1lisis de la Situaci\u00f3n de Salud Ministerio de Salud y Desarrollo Social de la Naci\u00f3n Argentina: Bolet\u00edn Integrado de Vigilancia n\u00b0 458 SE28\/2019 pp. 35\u201343.2019https:\/\/bancos.salud.gob.ar\/sites\/default\/files\/2020\u201001\/boletin\u2010integrado\u2010vigilancia\u2010n458.pdf"},{"key":"e_1_2_13_9_1","unstructured":"Direcci\u00f3n de Sangre y Hemoderivados.Ministerio de Salud de la Naci\u00f3n Argentina: Criterios para la selecci\u00f3n de donantes de sangre RM797\/13\u20101507\/15 2da. Edici\u00f3n 2016.https:\/\/bancos.salud.gob.ar\/sites\/default\/files\/2018\u201010\/0000001172cnt\u2010criterios\u2010seleccion\u2010donantes\u20102018.pdf"},{"key":"e_1_2_13_10_1","unstructured":"Ministerio de Salud.Presidencia de la Naci\u00f3n: Decreto Nacional 1.338\/2004. Decreto Reglamentario de la Ley de Sangre Humana N\u00b0 22.990. Bolet\u00edn Oficial Rep\u00fablica Argentina Oct de 2004. Id SAIJ: DN20040001338.http:\/\/www.saij.gob.ar\/1338\u2010nacional\u2010decreto\u2010reglamentario\u2010ley\u2010sangre\u2010humana\u2010n\u201022990\u2010dn20040001338\u20102004\u201009\u201030\/123456789\u20100abc\u2010833\u20101000\u20104002soterced"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.CPJ.0000435752.17621.48"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17707"},{"issue":"4","key":"e_1_2_13_13_1","first-page":"361","article-title":"Inmunoensayo quimioluminiscente para s\u00edfilis en donantes de sangre: \u00bfLos valores de lectura se correlacionan con el estado de la infecci\u00f3n?","volume":"57","author":"Rios Trevisan A","year":"2023","journal-title":"Acta Bioqu\u00edm Cl\u00edn Latinoam"},{"key":"e_1_2_13_14_1","first-page":"240","article-title":"Tamizaje de S\u00edfilis y HIV en Donantes de Sangre de CentrosRegionales de Hemoterapia de Salta, Jujuy y Tucum\u00e1n entre 2014 y 2018","author":"L\u00f3pez G","year":"2019","journal-title":"Rev Argentina Transfus"},{"key":"e_1_2_13_15_1","unstructured":"Organizaci\u00f3nPanamericana de la Salud.Suministro de sangre para transfusiones en los pa\u00edses de Am\u00e9rica Latina y el Caribe 2016\u20132017. 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