{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:23:34Z","timestamp":1762273414824,"version":"3.43.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T00:00:00Z","timestamp":1737331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009033","name":"NHS Blood and Transplant","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009033","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A large, retrospective study was designed to interrogate current NHS Blood and Transplant (NHSBT) HLA matching strategies for the provision of HLA selected platelets (HLA SP) and to determine whether additional factors such as ABO blood group matching, patient diagnosis, patient and\/or donor age, sex, ethnicity, age of platelet unit at transfusion and possibly seasonal variation also play a role in transfusion efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Data for 56\u2009640 HLA SP transfusions over a 3\u2010year period were collected. Transfusions with missing data for any factor under consideration were excluded, resulting in a cohort of 13\u2009044 transfusions for analysis. Univariable and multivariable regression models were used to determine if any factors influenced an increase in platelet count of \u226510 \u00d7\u200910<jats:sup>9<\/jats:sup>\/L. A stepwise logistic regression was applied, such that each influential factor was adjusted for effects on other factors included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>HLA match grade was confirmed as a significant factor in transfusion efficacy, with ABO mismatched units 20% less likely to give an adequate platelet increment (\u226510 \u00d7\u200910<jats:sup>9<\/jats:sup>\/L). Platelet donor age, gender and ethnicity were not significant. Conversely, patient diagnosis, ethnicity, gender and age showed significant associations with platelet increments. Some seasonal variation in efficacy of platelet transfusion was also demonstrated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study has demonstrated the efficacy of HLA SP transfusions in refractory patients with a wide range of diagnoses, the importance of HLA match grade, plus the marginal effect of ABO matching. A wide range of donor\u2010related factors was excluded, while a number of patient\u2010related factors were identified, requiring more extensive investigation in ongoing and independent studies, with implications for donor registry, clinical and laboratory practices.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13123","type":"journal-article","created":{"date-parts":[[2025,1,20]],"date-time":"2025-01-20T19:35:13Z","timestamp":1737401713000},"page":"205-214","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Factors affecting the efficacy of human leukocyte antigen\u2010selected platelet provision: A large retrospective study in the <scp>U<\/scp>nited <scp>K<\/scp>ingdom"],"prefix":"10.1111","volume":"35","author":[{"given":"W. M.","family":"Howell","sequence":"first","affiliation":[{"name":"Pathology Service Development NHS Blood and Transplant (NHSBT), Newcastle Centre  Newcastle UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Quaye","sequence":"additional","affiliation":[{"name":"Histocompatibility &amp; Immunogenetics NHSBT Colindale Centre  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Mumford","sequence":"additional","affiliation":[{"name":"Statistics and Clinical Research NHSBT Stoke Gifford Centre  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Statistics and Clinical Research NHSBT Stoke Gifford Centre  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Mepani","sequence":"additional","affiliation":[{"name":"Histocompatibility &amp; Immunogenetics NHSBT Colindale Centre  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Histocompatibility &amp; Immunogenetics NHSBT Colindale Centre  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5678-2799","authenticated-orcid":false,"given":"C. J.","family":"Brown","sequence":"additional","affiliation":[{"name":"Histocompatibility &amp; Immunogenetics NHSBT Colindale Centre  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14316"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.17824"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199502060-00015"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.2011.01474.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.2012.01852.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.12739"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15333"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2020.02.005"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14423"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12612"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020007199"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.18036"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1991.31591263191.x"},{"key":"e_1_2_11_15_1","first-page":"1035","article-title":"Factors associated with response to platelet transfusion following hematopoietic stem cell transplantation","volume":"17","author":"Klumpp TR","year":"1996","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15530"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-08-2724"},{"key":"e_1_2_11_18_1","unstructured":"Guidelines for the Blood Transfusion Services in the UK.https:\/\/transfusionguidelines.org\/red-book"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.1734"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2017.04.001"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16358"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-11-393165"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1988.28188127957.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-023-03085-6"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.06.054"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018028662"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15728"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.13123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:41:44Z","timestamp":1754905304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.13123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,20]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/tme.13123"],"URL":"https:\/\/doi.org\/10.1111\/tme.13123","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"type":"print","value":"0958-7578"},{"type":"electronic","value":"1365-3148"}],"subject":[],"published":{"date-parts":[[2025,1,20]]},"assertion":[{"value":"2024-09-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-12","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}