{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:55:55Z","timestamp":1755222955157,"version":"3.43.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Red blood cell (RBC) alloimmunization is rarely reported in infants less than 4\u20136\u2009months of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Materials<\/jats:title><jats:p>Blood group and antibody screening used the gel card technique. All blood products were leukoreduced. All RBC doses transfused were group O, E\u2010neg, K\u2010neg but the pooled platelets transfused on day 45 and 61 included donors who were K\u2010pos, and that transfused on day 61 also included an E\u2010pos donor.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We report a group O neonate with haemophagocytic lymphohistiocytosis (HLH) who developed alloantibodies to E and K antigens at 65\u2009days (9\u2009weeks) of age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HLH is an inflammatory, \u2018hyperimmune\u2019 state, and alloimmunization is more likely when inflammation is present. If significant inflammation is present, transfusions should be avoided if possible.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13132","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T19:03:13Z","timestamp":1739214193000},"page":"291-296","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Early alloimmunization in an infant to red cell antigens\u2014Rare but possible in the \u2018right\u2019 circumstances"],"prefix":"10.1111","volume":"35","author":[{"given":"Anwen","family":"Maddock","sequence":"first","affiliation":[{"name":"New Zealand Blood Service  Christchurch New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sue","family":"Warrington","sequence":"additional","affiliation":[{"name":"New Zealand Blood Service  Christchurch New 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