{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:55:55Z","timestamp":1755222955590,"version":"3.43.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To report a delayed case of severe haemolytic disease of the foetus and newborn (HDFN) due to Anti\u2010Ce.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>HDFN due to maternal antibodies is potentially fatal. As a result, antibody levels and foetal anaemia are periodically monitored and risk assessed throughout pregnancy. HDFN due to Anti\u2010Ce is rare.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A 29\u2010year\u2010old Caucasian female with low titre Anti\u2010Ce and Anti\u2010e antenatally delivered a term baby girl that required multiple transfusions and hospital admissions early in life. The apparent clinical severity of HDFN resulted in investigative testing of a maternal admission sample at delivery for titre levels. Anti\u2010Ce was identified as the cause of HDFN in this case, following an eightfold increase in titre levels from week 28 gestation (titre\u2009=\u20094) to term (titre\u2009=\u200932).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The severe HDFN outlined in this case was unexpected due to the antibody specificity and low titres antenatally. The Anti\u2010Ce with a titre of 32 implicated in this study is on the threshold for specialist foetal team involvement and vigilant monitoring as per BSH guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anti\u2010Ce titre monitoring beyond 28\u2009weeks gestation and specialist foetal team involvement early in pregnancy should be considered despite current BSH Guidelines, along with extended neonatal monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13134","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T05:37:40Z","timestamp":1741757860000},"page":"287-290","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010Ce in haemolytic disease of the foetus and newborn"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3075-396X","authenticated-orcid":false,"given":"Rebecca","family":"O'Grady","sequence":"first","affiliation":[{"name":"Transfusion Medicine Laboratory The Coombe Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Haematology The National Maternity Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Miletin","sequence":"additional","affiliation":[{"name":"Department of Paediatrics &amp; Newborn Medicine The Coombe Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Regan","sequence":"additional","affiliation":[{"name":"Obstetrics and Maternal Fetal Medicine The Coombe Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fergus","family":"Guilfoyle","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Laboratory The Coombe Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edel","family":"Scally","sequence":"additional","affiliation":[{"name":"Red Cell Immunohaematology &amp; Diagnostics Laboratory The Irish Blood Transfusion Service  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Flynn","sequence":"additional","affiliation":[{"name":"Transfusion Medicine Laboratory The Coombe Hospital  Dublin Ireland"},{"name":"Department of Haematology St. James's Hospital  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,5]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1941.02820090025006"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(94)90477-4"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.2.375"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.87.2.189"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.298.6689.1671"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01625.x"},{"key":"e_1_2_13_8_1","first-page":"452","article-title":"Hemolytic disease of the newborn due to anti\u2010Ce (rhi) in twins","volume":"8","author":"Dahl JR","year":"1968","journal-title":"Vox Sang"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2000.40050571.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2000.00268.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3148.2003.00412.x"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tme.12299"},{"volume-title":"The Blood Group Antigens Facts Book","year":"1997","author":"Reid ME","key":"e_1_2_13_13_1"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.13134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T09:41:28Z","timestamp":1754905288000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.13134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,5]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1111\/tme.13134"],"URL":"https:\/\/doi.org\/10.1111\/tme.13134","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"type":"print","value":"0958-7578"},{"type":"electronic","value":"1365-3148"}],"subject":[],"published":{"date-parts":[[2025,3,5]]},"assertion":[{"value":"2025-01-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}