{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T19:37:26Z","timestamp":1771357046569,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to explore the impact of pressurisation and simultaneous warming at a combination of 50\u2009kPa and 46\u00b0C on the quality of suspended red blood cells in an ex vivo environment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>During massive rapid blood transfusion, pressure and temperature\u2010controlled blood warming devices are often used to prevent hypothermia caused by the infusion of large amounts of cold blood. If the pressure and temperature are not properly applied during this process, it can endanger the patient's life safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Materials<\/jats:title><jats:p>400\u2009mL of human suspended red blood cells stored at 2\u20136\u00b0C were subjected to pressure and simultaneous warming at a combination of 50\u2009kPa and 46\u00b0C. Changes in blood temperature and blood quality\u2010related indicators before and after warming under pressure were detected, with the procedure repeated six times.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the ex vivo simulated test environment, there were no statistically significant differences in routine blood indicators, biochemical indicators, and hemolysis rates of suspended red blood cells before and after pressure and warming transfusion at 50\u2009kPa pressure and 46\u00b0C temperature (P&gt;0.05). There were no significant changes in osmotic fragility after pressure and warming transfusion, and no obvious hemolysis was observed in the morphology of suspended red blood cells under an electron microscope.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the ex vivo simulated test environment, pressure and warming transfusion at 50\u2009kPa pressure and 46\u00b0C temperature had no significant impact on blood quality, and the blood quality met the standards for the use of blood products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.13141","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T08:31:09Z","timestamp":1746174669000},"page":"366-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The impact of pressure and temperature on the quality of suspended red blood cells: An ex vivo simulation study"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-9682","authenticated-orcid":false,"given":"Chunyu","family":"Feng","sequence":"first","affiliation":[{"name":"School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Department of Anesthesiology Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Department of Blood Transfusion Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haimei","family":"Ma","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Department of Blood Transfusion Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0060-9169","authenticated-orcid":false,"given":"Huan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine Tsinghua University  Beijing China"},{"name":"Department of Anesthesiology Beijing Tsinghua Changgung Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14450"},{"key":"e_1_2_9_3_1","first-page":"638","volume-title":"The American Society of Hematology Education Program Book","author":"Szczepiorkowski ZM","year":"2013"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc5686"},{"key":"e_1_2_9_5_1","unstructured":"OoleyP.AABB Standards for Blood Banks and Transfusion 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