{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T04:46:17Z","timestamp":1766465177090,"version":"3.48.0"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Despite efforts to standardise practice using evidence\u2010based guidelines, fresh frozen plasma (FFP) remains the blood component most frequently prescribed inappropriately. This study assessed the appropriateness of FFP transfusion in two tertiary teaching hospitals and analysed the characteristics of appropriate and inappropriate transfusions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients who had undergone FFP transfusion between October and December 2022 at two tertiary teaching hospitals were retrospectively analysed. Only the initial FFP transfusion data were analysed for each patient. Patient characteristics; laboratory test results, including prothrombin time, international normalised ratio, and activated partial thromboplastin time; and the association of FFP transfusion with various factors were examined. Sub\u2010therapeutic dosing was defined as the transfusion of \u22642\u2009units of FFP. FFP transfusions were classified into eight groups based on a classification algorithm to determine their appropriateness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 584 FFP transfusions (2301\u2009units) were analysed, with 42.1% involving subtherapeutic dosing. FFP transfusions were performed in the intensive care unit (ICU; 30.5%), general ward (24.8%), operating room (21.1%), and emergency room (22.9%). Overall, 51.5% of FFP transfusions were deemed appropriate, with significant variations being observed between the hospitals (Hospital B vs. Hospital A: 73.2% vs. 35.3%). Inappropriate FFP transfusions were associated with a higher INR, with 73.4% of them being associated with severe bleeding and\/or surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In conclusion, 40.6% of FFP transfusions were deemed inappropriate in the present study owing to failure to meet laboratory criteria. The present study provides valuable insights into the optimisation of plasma transfusion practices and emphasises the requirement for institution\u2010specific management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.13142","type":"journal-article","created":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T00:43:55Z","timestamp":1748393035000},"page":"548-555","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the appropriateness of fresh frozen plasma transfusions in two tertiary teaching hospitals"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0004-2801","authenticated-orcid":false,"given":"Jongmin","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine Pusan National University School of Medicine  Yangsan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6150-5219","authenticated-orcid":false,"given":"Kae Lyang","family":"Koo","sequence":"additional","affiliation":[{"name":"Office of Transfusion Management Pusan National University Yangsan Hospital  Yangsan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9021-5632","authenticated-orcid":false,"given":"Hyun\u2010Ji","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Pusan National University School of Medicine  Yangsan South Korea"},{"name":"Office of Transfusion Management Pusan National University Yangsan Hospital  Yangsan South Korea"},{"name":"Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital  Yangsan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3989-2037","authenticated-orcid":false,"given":"Hyung\u2010Hoi","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Pusan National University School of Medicine  Yangsan South Korea"},{"name":"Biomedical Research Institute Pusan National University Hospital  Busan South Korea"},{"name":"Biomedical Informatics Unit Pusan National University School of Medicine  Yangsan South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"AABB.Circular of information for the use of human blood and blood components: AABB Bethesda MD. 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