{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T04:46:01Z","timestamp":1766465161539,"version":"3.48.0"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001130","name":"Gerber Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2025,12]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n This protocol describes a study to test a commercial blood warming device in warming blood transfusions to prevent hypothermia associated with packed red blood cell (PRBC) transfusions in very preterm infants.<\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n \n Very preterm infants receiving blood transfusions warmed by a commercial blood warmer will have less central body hypothermia post transfusion (abdominal temperatures <36.5\u00b0C) and\/or a higher mean abdominal temperature for the hour after the transfusion is complete compared to those receiving blood transfusions by standard of care. This trial has been registered with\n Clinicaltrials.gov<\/jats:ext-link>\n (trial number NCT05170633).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this trial, which is funded by The Gerber Foundation and adhered to the\n SPIRIT2013<\/jats:styled-content>\n checklist, 140 very preterm infants with an order to receive\n PRBCs<\/jats:styled-content>\n will be randomised into a standard of care group to receive one\n PRBC<\/jats:styled-content>\n transfusion over 3\u2009h with blood in a syringe at room temperature or into the intervention group to receive one\n PRBC<\/jats:styled-content>\n transfusion over 3\u2009h using a Hotline\u00ae Blood and Fluid Warmer. Abdominal skin temperatures will be measured every minute through a blood transfusion using a skin thermistor and datalogger.\n <\/jats:p>\n <\/jats:sec>\n \n Data analysis<\/jats:title>\n \n Descriptive statistics will be computed for each group to compare demographics and all infant pre\u2010, during, and post\u2010transfusion body temperatures. A student\n t\u2010<\/jats:italic>\n test will be used to compare the groups on mean post\u2010transfusion temperatures as a primary outcome variable. To examine thermal change over time between the two groups, linear mixed models with a random intercept will be utilised.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n This trial began in January 2022, in a South Carolina neonatal intensive care unit and is ongoing.<\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n This RCT will determine if warming PRBC transfusions will prevent hypothermia in preterm infants during and after blood transfusions. Results from this trial will be used to design national standards for blood transfusions in preterm infants to decrease morbidity and mortality.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tme.13143","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T06:58:31Z","timestamp":1747292311000},"page":"582-586","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating a blood warming device for packed red blood cell transfusions to decrease hypothermia in very preterm infants: A randomised control trial protocol"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9152-3223","authenticated-orcid":false,"given":"Kayla C.","family":"Everhart","sequence":"first","affiliation":[{"name":"College of Nursing University of South Carolina Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Wirth","sequence":"additional","affiliation":[{"name":"College of Nursing University of South Carolina Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor N.","family":"Iskersky","sequence":"additional","affiliation":[{"name":"Department of Neonatology PEDIATRIX\/PRISMA Health Richland Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin B.","family":"Dail","sequence":"additional","affiliation":[{"name":"Health Sciences Endowed Professor University of South Carolina College of Nursing Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"OstermanMJ HamiltonBE MartinJA DriscollAK ValenzuelaCP.Births: final data for 2020.2022.","key":"e_1_2_13_2_1","DOI":"10.15620\/cdc:112078"},{"key":"e_1_2_13_3_1","first-page":"1","article-title":"Births in the United States, 2022","volume":"477","author":"Martin JA","year":"2023","journal-title":"NCHS Data Brief"},{"doi-asserted-by":"publisher","key":"e_1_2_13_4_1","DOI":"10.1016\/j.semperi.2021.151390"},{"doi-asserted-by":"publisher","key":"e_1_2_13_5_1","DOI":"10.1016\/j.puhe.2014.03.010"},{"doi-asserted-by":"publisher","key":"e_1_2_13_6_1","DOI":"10.1002\/nur.21923"},{"doi-asserted-by":"publisher","key":"e_1_2_13_7_1","DOI":"10.1111\/1552\u20106909.12240"},{"doi-asserted-by":"publisher","key":"e_1_2_13_8_1","DOI":"10.1016\/j.tsep.2020.100553"},{"unstructured":"World Health Organization.https:\/\/www.who.int\/workforcealliance\/knowledge\/resources\/who_2015_h4_chws_srmncah.pdf.","key":"e_1_2_13_9_1"},{"issue":"2","key":"e_1_2_13_10_1","first-page":"15","article-title":"Thermoregulation in neonates","volume":"13","author":"Thomas K","year":"1994","journal-title":"Neonatal Network"},{"doi-asserted-by":"publisher","key":"e_1_2_13_11_1","DOI":"10.1016\/j.jnn.2020.07.003"},{"key":"e_1_2_13_12_1","first-page":"43","article-title":"Examining practice variation used for packed red blood cell transfusions for preterm infants in neonatal intensive care units across the United States","volume":"12","author":"Everhart KC","year":"2022","journal-title":"Res Rep Neonatol"},{"doi-asserted-by":"publisher","key":"e_1_2_13_13_1","DOI":"10.7326\/0003-4819-158-3-201302050-00583"},{"doi-asserted-by":"publisher","key":"e_1_2_13_14_1","DOI":"10.1097\/NNR.0000000000000483"},{"doi-asserted-by":"publisher","key":"e_1_2_13_15_1","DOI":"10.1016\/j.jbi.2008.08.010"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.13143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T03:34:21Z","timestamp":1766460861000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.13143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/tme.13143"],"URL":"https:\/\/doi.org\/10.1111\/tme.13143","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"type":"print","value":"0958-7578"},{"type":"electronic","value":"1365-3148"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"assertion":[{"value":"2024-09-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}