{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:01:46Z","timestamp":1759881706210,"version":"build-2065373602"},"reference-count":52,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T00:00:00Z","timestamp":1755561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This systematic review and meta\u2010analysis aim to evaluate the changes in coagulation factor and bacterial contamination by extending the preservation period of thawed cryoprecipitate for 5\u2009days at refrigerated temperatures. Literature searches were conducted from three different databases, and the literature was screened according to the inclusion criteria. The quality of the literature was assessed using the Risk of Bias in Non\u2010randomised Studies\u2014of Interventions (ROBINS\u2010I) tool, and a meta\u2010analysis was conducted using RevMan5.3 software. Finally, five studies met the inclusion criteria. The meta\u2010analysis results show that fibrinogen concentration remains stable after storing the thawed cryoprecipitate at refrigerated temperatures for 5\u2009days Mean Difference (MD)\u2009=\u2009\u22120.0802, 95% Confidence Interval (CI)\u2009=\u2009\u22120.4220, 0.2616, <jats:italic>p<\/jats:italic>\u2009=\u20090.65. The systematic review showed that thawed cryoprecipitate stored at refrigerated temperatures for 120\u2009h had a slight decrease in factor VIII activity but still met the current standard, von Willebrand factor content level remained relatively stable, factor XIII activity showed no significant decrease, and no bacterial contamination was detected. Overall, the available data suggest that fibrinogen concentration remained stable and no bacterial contamination was detected after storing the thawed cryoprecipitate at refrigerated temperatures for 5\u2009days. The lack of assessment of aggregate formation is an important limitation of this review. In addition, the number of relevant studies is still relatively limited, and further extensive studies are necessary to confirm this conclusion.<\/jats:p>","DOI":"10.1111\/tme.70009","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T00:32:31Z","timestamp":1755649951000},"page":"415-423","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Storage of thawed cryoprecipitate for 5\u2009days at refrigerated temperatures: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4335-7985","authenticated-orcid":false,"given":"Shuhong","family":"Xie","sequence":"first","affiliation":[{"name":"Division of Transfusion Medicine Suzhou Blood Center  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longhai","family":"Tang","sequence":"additional","affiliation":[{"name":"Transfusion Research Laboratory Suzhou Blood Center  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Suzhou Blood Center  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qungang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Quality Management Department Suzhou Blood Center  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Transfusion Medicine Suzhou Blood Center  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,19]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"GB 18469\u20102012. 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