{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:51:59Z","timestamp":1758055919979,"version":"3.44.0"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T00:00:00Z","timestamp":1757894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Annually millions of platelet concentrate (PC) are transfused worldwide. The decision regarding PC transfusion is often complex; therefore, the implementation of a hospital programme designed to streamline and facilitate the decision\u2010making process is beneficial. Such a programme helps standardise transfusion practices, ensures that PCs are used appropriately, while also optimising patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The study aimed to analyse the impact of a new hospital utilisation improvement programme on PC transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Materials<\/jats:title><jats:p>We performed a retrospective analysis of all PC transfusions in adult patients hospitalised in our large academic medical centre. The analysed time covered 12\u2010month periods before and after the introduction of the program, which was based on the most recent clinical practice guidelines from the Association for the Advancement of Blood and Biotherapies. Indications for PC transfusion were divided into prophylactic and therapeutic. The new program was made available on the hospital intranet, obligatory e\u2010learning was required from all clinical and laboratory personnel, and a computerised physician order entry was modified.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The transfusion rate in the whole analysed period was 0.17%. The median pre\u2010transfusion platelet count before and after implementation of the programme was 28 (IQR 15.0\u201350.0) and 24 (IQR 12.0\u201342.0)\u2009\u00d7\u200910<jats:sup>9<\/jats:sup>\/L, respectively. Percentage of therapeutic transfusions increased from 46.7% to 57.7%. Overall the appropriateness of transfusions went up from 48.4% to 59.9%, and was higher for therapeutic (70.2% vs. 60.0%) than prophylactic (45.8% vs. 38.3%) transfusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Simple hospital utilisation improvement programme, adjusted to the local population and backed by e\u2010learning and modification of a computerised physician order entry, can lead to a more restrictive use of PC transfusions in patients with thrombocytopenia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tme.70017","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T10:29:00Z","timestamp":1757932140000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluating the effects of a hospital utilisation improvement program on platelet transfusions: A pre\u2010post study"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4347-5631","authenticated-orcid":false,"given":"Piotr F.","family":"Czempik","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Intensive Care, Faculty of Medical Sciences in Katowice Medical University of Silesia  Katowice Poland"},{"name":"Transfusion Committee University Clinical Center of the Medical University of Silesia in Katowice  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3936-5683","authenticated-orcid":false,"given":"Jakub","family":"Rudzki","sequence":"additional","affiliation":[{"name":"Students' Scientific Society, Department of Anesthesiology and Intensive Care, Faculty of Medical Sciences in Katowice Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8378-435X","authenticated-orcid":false,"given":"Micha\u0142","family":"Porada","sequence":"additional","affiliation":[{"name":"Students' Scientific Society, Department of Anesthesiology and Intensive Care, Faculty of Medical Sciences in Katowice Medical University of Silesia  Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,15]]},"reference":[{"issue":"4","key":"e_1_2_12_2_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.jcrc.2005.09.008","article-title":"Thrombocytopenia in medical\u2010surgical critically ill patients: prevalence, incidence, and risk factors","volume":"20","author":"Crowther MA","year":"2005","journal-title":"J Crit Care"},{"issue":"8","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1097\/00003246-200208000-00015","article-title":"Thrombocytopenia in patients in the medical intensive care unit: bleeding prevalence, transfusion requirements, and outcome","volume":"30","author":"Strauss R","year":"2002","journal-title":"Crit Care Med"},{"issue":"26","key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"3032","DOI":"10.1182\/blood-2016-09-693655","article-title":"How I evaluate and treat thrombocytopenia in the intensive care unit patient","volume":"128","author":"Greinacher A","year":"2016","journal-title":"Blood"},{"issue":"2","key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1378\/chest.10-2243","article-title":"The frequency and clinical significance of thrombocytopenia complicating critical illness: a systematic review","volume":"139","author":"Hui P","year":"2011","journal-title":"Chest"},{"issue":"1","key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/aas.13699","article-title":"Thrombocytopenia in intensive care unit patients: a scoping review","volume":"65","author":"Jonsson AB","year":"2021","journal-title":"Acta Anaesthesiol Scand"},{"issue":"1","key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1182\/asheducation-2010.1.135","article-title":"Thrombocytopenia in the intensive care unit patient","volume":"2010","author":"Greinacher A","year":"2010","journal-title":"Hematology"},{"issue":"3","key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.7326\/M14-1589","article-title":"Platelet transfusion: a clinical practice guideline from the AABB","volume":"162","author":"Kaufman RM","year":"2015","journal-title":"Ann Intern Med"},{"issue":"3","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/bjh.14423","article-title":"Guidelines for the use of platelet transfusions","volume":"176","author":"Estcourt LJ","year":"2017","journal-title":"Br J Haematol"},{"issue":"5","key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/tme.12155","article-title":"Why has demand for platelet components increased? 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