{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T11:27:06Z","timestamp":1770550026054,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Thrombocytopenia is common in neonates, managed with platelet transfusions at defined dose. The product type varies from neonatal\u2010specific units using platelet additive solutions to adult products split into multiple paediatric units. In low\u2010middle\u2010income countries, whole blood\u2010derived random donor platelets (RDP) are common while western countries use split adult single donor apheresis platelets (SDAP). We aimed to assess preliminary effectiveness of split, volume\u2010reduced single donor apheresis platelets (NeoVR\n                      <jats:bold>s<\/jats:bold>\n                      \u2010SDAP) in neonatal thrombocytopenia and observe early post\u2010transfusion outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Study was conducted from August 2024 to January 2025 at a tertiary healthcare centre. Persistent thrombocytopenic neonates admitted to the NICU were transfused with NeoVR\n                      <jats:bold>s<\/jats:bold>\n                      \u2010SDAP prepared using Spectra Optia\u00ae with modified program yielding an adult dose (300 \u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      ) in a reduced 100\u2009mL of product volume. These were split into 2\u20135 aliquots for transfusion. Post\u2010transfusion platelet increments and percentage recovery were assessed after 20\u201324\u2009h.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirteen neonates' 77% preterm, 69.2% VLBW with sepsis received 46 NeoVR\n                      <jats:bold>s<\/jats:bold>\n                      \u2010SDAP. 10\u2009mL of this product contained nearly 3 times more platelets than RDP and 1.5 times more than adult SDAP of same volume. The mean transfused dose was 70.56\u2009\u00b1\u200914.21\u2009\u00d7\u200910\n                      <jats:sup>9<\/jats:sup>\n                      platelets. Median platelet increment was 64\u2009500\/\u03bcL versus 15\u2009477\/\u03bcL for RDP (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Platelet recovery ranged from 7.5%\u201352.5%. Split products reduced donor exposure by 56.5%. Survival was 62%, without any transfusion\u2010related adverse events.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      NeoVR\n                      <jats:bold>s<\/jats:bold>\n                      \u2010SDAP may be potential alternative in persistent neonatal thrombocytopenia, offering better increments and recovery, reduced donor exposure, and leukoreduction. Further RCTs comparing NeoVR\n                      <jats:bold>s<\/jats:bold>\n                      \u2010SDAP and RDP are recommended.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.70024","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:25:27Z","timestamp":1763551527000},"page":"72-78","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Improvising neonatal thrombocytopenia management: Insights from split, volume\u2010reduced, single\u2010donor apheresis platelets (NeoVRs\u2010SDAP)"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7684-8567","authenticated-orcid":false,"given":"Yashaswi","family":"Dhiman","sequence":"first","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Himalayan Institute of Medical Sciences Swami Rama Himalayan University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saikat","family":"Patra","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Himalayan Institute of Medical Sciences Swami Rama Himalayan University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chinmay","family":"Chetan","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Himalayan Institute of Medical Sciences Swami Rama Himalayan University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manish","family":"Raturi","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Himalayan Institute of Medical Sciences Swami Rama Himalayan University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoham","family":"Majumder","sequence":"additional","affiliation":[{"name":"Department of Neonatology AIIMS  Kalyani India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolika","family":"Nautiyal","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Himalayan Institute of Medical Sciences Swami Rama Himalayan University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tushar","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Himalayan Institute of Medical Sciences Swami Rama Himalayan University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dushyant Singh","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Immunohematology and Blood Transfusion, Himalayan Institute of Medical Sciences Swami Rama Himalayan University  Dehradun Uttarakhand India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2008.141"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2007\u20102850"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01592.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7211509"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.12.4402"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.09.64"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81705-6"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.2002.00208.x"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2020.10.002"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14233"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000899"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2013.46"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2019.104845"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-024-05657-4"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/09537104.2021.1962837"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17109"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41372-025-02347-5"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365163"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16857"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-019-01164-z"},{"key":"e_1_2_13_22_1","article-title":"New 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