{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:50:18Z","timestamp":1785858618494,"version":"3.56.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515140179"],"award-info":[{"award-number":["2023A1515140179"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Objectives<\/jats:title>\n                    <jats:p>There is limited knowledge regarding cefamandole\u2010related drug\u2010induced immune haemolytic anaemia (DIIHA). We conducted a comprehensive serological and clinical follow\u2010up study of a case of cefamandole\u2010induced DIIHA to improve understanding of this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A patient with advanced hepatocellular carcinoma developed severe haemolytic anaemia along with significant worsening of hepatic and renal function after intravenous cefamandole was administered for a urinary tract infection. Serological testing included the direct antiglobulin tests (DATs), irregular red blood cell (RBC) antibody screening and detection of cefamandole\u2010dependent antibodies using two standard methods for drug\u2010dependent antibodies: \u2018testing in the presence of soluble drug\u2019 and \u2018testing drug\u2010treated RBCs\u2019, which were performed after cefamandole discontinuation. Clinical follow\u2010up was conducted for 41\u2009days after drug cessation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The results of DAT for anti\u2010IgG and anti\u2010C3d were strongly positive, while irregular RBC antibody screening was negative. Plasma samples collected at different points from 13 to 38\u2009days after cefamandole discontinuation were incubated with cefamandole\u2010coated RBCs at 37\u00b0C, revealing both IgM and IgG cefamandole\u2010dependent antibodies, with a maximum titre of 16. Following treatment with blood transfusion, intravenous immunoglobulin (IVIG), and methylprednisolone, anaemia and organ dysfunction showed marked improvement. Therefore, the patient was diagnosed with cefamandole\u2010induced DIIHA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study may be the second serological analysis and the first comprehensive clinical follow\u2010up of cefamandole\u2010induced DIIHA. It demonstrates that cefamandole\u2010dependent antibodies can activate complement, leading to severe haemolytic anaemia and hepatic and renal impairment. The \u2018testing drug\u2010treated RBCs\u2019 method is suitable for detecting cefamandole\u2010dependent antibodies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.70037","type":"journal-article","created":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:12:01Z","timestamp":1760058721000},"page":"252-259","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Drug\u2010induced immune haemolytic anaemia caused by cefamandole sodium: Complete serologic studies and clinical follow\u2010up"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9459-9688","authenticated-orcid":false,"given":"Yuanjun","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine Dongguan Maternal and Child Health Hospital  Dongguan China"},{"name":"Dongguan Key Laboratory for Precision Diagnosis and Blood Management of Immune Haemolytic Diseases Dongguan Maternal and Child Health Hospital  Dongguan China"},{"name":"Department of Laboratory Medicine Dongguan Maternal and Child Health Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6298-7370","authenticated-orcid":false,"given":"Yinglin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine Dongguan Maternal and Child Health Hospital  Dongguan China"},{"name":"Dongguan Key Laboratory for Precision Diagnosis and Blood Management of Immune Haemolytic Diseases Dongguan Maternal and Child Health Hospital  Dongguan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine The Sixth People's Hospital of Huizhou  Huizhou 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