{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T03:26:50Z","timestamp":1785036410199,"version":"3.55.0"},"reference-count":59,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Solid organ transplant is associated with high rates of anaemia and transfusion, but there is little comparative data on interventions such as erythropoietin\u2010stimulating agents (ESAs) and intravenous (IV) iron. We conducted a systematic review examining the association of ESAs and IV iron with outcomes in adults undergoing solid organ transplant. This review was registered with PROSPERO (CRD42023474722). EMBASE and MEDLINE were searched from inception to April 11, 2025. Identified studies included adults (\u226518\u2009years of age) undergoing heart, liver, lung, or kidney transplant who received any ESA and\/or IV iron before, during, or up to 1 month following solid organ transplant surgery compared to patients who did not. Article screening, full text review and data extraction were performed by two independent reviewers. The primary outcome of interest was transfusion volume, with secondary outcomes including haematological parameters, graft\u2010related outcomes and rates of major morbidity and mortality. Results were analysed descriptively and compiled into tables, and the risk of bias was assessed using the CLARITY framework. From 1693 studies identified, 22 were included (kidney transplant,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916; heart transplant or Left Ventricular Assist Device as a bridge to transplant,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20094; liver transplant,\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092). Due to heterogeneity in design, interventions and outcomes, meta\u2010analysis was not attempted. The quality of evidence was graded as Very Low. On the whole, a comprehensive strategy implementing ESAs and IV iron may improve haematological parameters and facilitate transfusion avoidance. High\u2010quality prospective studies assessing the impact of protocols for haemoglobin optimisation and transfusion avoidance in solid organ transplant are needed.\n                  <\/jats:p>","DOI":"10.1111\/tme.70045","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T01:16:27Z","timestamp":1765415787000},"page":"95-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The effect of perioperative erythropoietin\u2010stimulating agents and intravenous iron on patient outcomes following solid organ transplantation: A systematic review"],"prefix":"10.1111","volume":"36","author":[{"given":"Frank","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Eichbaum","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Cserti\u2010Gazdewich","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren","family":"Mullane","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pharmacology, &amp; Therapeutics The University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick W.","family":"Lombard","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5719-9685","authenticated-orcid":false,"given":"Jeremy W.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Vanderbilt University School of Medicine  Nashville Tennessee USA"},{"name":"Department of Pathology, Microbiology, and Immunology Vanderbilt University Medical Center  Nashville Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Pavenski","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathobiology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Englesakis","sequence":"additional","affiliation":[{"name":"Library &amp; Information Services, University Health Network\u2010Toronto General Hospital  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Dotto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pharmacology, &amp; Therapeutics The University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Cho","sequence":"additional","affiliation":[{"name":"Michael G. DeGroote School of Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Leonard\u2010Reixa","sequence":"additional","affiliation":[{"name":"Department of Anesthesia and Pain Management Sinai Health System, Women's College Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Trudeau","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Pharmacology, &amp; Therapeutics The University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew W.","family":"Shih","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justyna","family":"Bartoszko","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine University of Toronto  Toronto Ontario Canada"},{"name":"Department of Anesthesia and Pain Management Sinai Health System, Women's College Hospital, University Health Network  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V114.22.3158.3158"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.698977"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/frtra.2023.1215130"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(07)61197\u20100"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15233"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399\u20100012.2011.01397.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3182054d06"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000006065"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/hematology.2019000063"},{"issue":"7","key":"e_1_2_11_11_1","first-page":"989","article-title":"Autologous versus allogeneic transfusion: patients' perceptions and experiences","volume":"160","author":"Graham ID","year":"1999","journal-title":"CMAJ"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168\u20108510(96)00879\u20102"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.2.508"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2024.06.007"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.883932"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2023.101484"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2023.05.010"},{"key":"e_1_2_11_19_1","unstructured":"CLARITY.Tool to Assess Risk of Bias in Cohort Studies. 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