{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:54:09Z","timestamp":1785858849503,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulmonary complications of transfusion are a leading cause of morbidity and mortality. Transfusion\u2010associated circulatory overload (TACO) is the most common, whereas transfusion\u2010related acute lung injury (TRALI) is less frequent but potentially fatal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe a pediatric case with overlapping features of TACO and TRALI following platelet transfusion and to highlight diagnostic and management challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We report the case of a 15\u2010year\u2010old patient with acute myeloid leukemia who developed acute respiratory compromise after platelet transfusion. Clinical findings, laboratory data (including pro\u2010BNP), imaging, and immunologic investigations were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Elevated pro\u2010BNP levels and signs of fluid overload were consistent with TACO. However, chest radiography demonstrated non\u2010cardiogenic pulmonary edema, and pre\u2010existing pulmonary involvement supported a diagnosis of type II TRALI. Management included immediate cessation of transfusion, oxygen therapy, and comprehensive evaluation with cytokine profiling, antibody screening, and advanced immunologic testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case illustrates the diagnostic complexity of transfusion\u2010related pulmonary complications, particularly when TACO and TRALI features overlap, and underscores the importance of a multidisciplinary approach to management and investigation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.70053","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T11:12:04Z","timestamp":1767697924000},"page":"295-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transfusion\u2010related pulmonary complications in paediatric acute myeloid leukaemia: A case report of transfusion\u2010associated circulatory overload (\n                    <scp>TACO<\/scp>\n                    ) and transfusion\u2010related acute lung injury (\n                    <scp>TRALI<\/scp>\n                    )"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2987-0903","authenticated-orcid":false,"given":"Mauro","family":"Guariento","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences, Dentistry, Pediatrics and Gynecology University of Verona  Verona Italy"},{"name":"Department of Pediatric Hemato\u2010Oncology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3916-4091","authenticated-orcid":false,"given":"Carlos","family":"Echecopar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2682-9664","authenticated-orcid":false,"given":"V\u00edctor","family":"Gal\u00e1n\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel Mart\u00ednez","family":"Romera","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta Gonz\u00e1lez","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonsoles San","family":"Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-3062","authenticated-orcid":false,"given":"V\u00edctor Quintero","family":"Calca\u00f1o","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Sisinni","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio P\u00e9rez","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hemato\u2010Oncology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora Viejo","family":"Llorente","sequence":"additional","affiliation":[{"name":"Department of Hematology La Paz University Hospital  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Kerguelen","family":"Fuentes","sequence":"additional","affiliation":[{"name":"Department of Hematology La Paz University Hospital  Madrid 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clinical factors of blood transfusion\u2010related acute lung injury and changes in levels of Treg\u2010related cytokines","volume":"2024","author":"International EM","year":"2024","journal-title":"Emerg Med Int"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.16805"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-022-02172-w"}],"container-title":["Transfusion 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