{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:53:01Z","timestamp":1789750381705,"version":"4.0.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Platelet transfusion is essential in managing thrombocytopenia in hemato\u2010oncology patients. This study aimed to determine the prevalence of platelet refractoriness (PR) and to evaluate the efficacy of crossmatch\u2010compatible single\u2010donor platelet (SDP) transfusions in patients with suspected platelet refractoriness.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>A two\u2010year quasi\u2010experimental study comprised adult and paediatric hemato\u2010oncology patients with two consecutive low corrected count increment (CCI) responses (&lt;7500\/\u03bcL) following SDP transfusions. Refractory patients with non\u2010immune causes were tried to be excluded as far as possible. Platelet crossmatching was performed using solid\u2010phase red cell adherence (SPRCA) technology. One\u2010hour post\u2010transfusion CCI and percentage platelet recovery (PPR) were evaluated between crossmatch\u2010compatible and incompatible transfusions. Statistical analyses included descriptive statistics as mean\u2009\u00b1\u2009standard deviation (SD), median with interquartile range (IQR), or frequencies (%). Multivariate regression analysis was used to identify predictors of transfusion response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 272 SDP transfused patients, 142 (52.2%) were refractory and of them, 101 were eligible for platelet crossmatching. Of the 166 SDP transfusions, 63.4% were crossmatch incompatible. Crossmatch\u2010compatible transfusions yielded significantly higher mean CCI (17\u2009788 vs. 11\u2009913,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and PPR (44.8% vs. 28.7%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Crossmatching demonstrated high sensitivity (84.8%) and NPV (86.4%) for detecting inadequate responses. Multivariate analysis identified platelet compatibility and age as significant predictors of transfusion efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Crossmatch\u2010compatible platelet transfusions significantly improve post\u2010transfusion CCI and PPR in alloimmunised hemato\u2010oncology patients. Crossmatch compatibility and patient age were identified as two independent predictors of adequate early platelet transfusion response (1\u2010h CCI, PPR and platelet increment).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.70058","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:43:05Z","timestamp":1769082185000},"page":"377-385","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A quasi\u2010experimental study evaluating the efficacy of crossmatch\u2010matched platelet transfusions in hemato\u2010oncology patients with suspected alloimmune platelet refractoriness: A single\u2010centre experience"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7785-7342","authenticated-orcid":false,"given":"Daljit","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine All India Institute of Medical Sciences\u2014Rishikesh  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Negi","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine All India Institute of Medical Sciences\u2014Rishikesh  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6157-1446","authenticated-orcid":false,"given":"Vaidehi","family":"Prasanth","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine All India Institute of Medical Sciences\u2014Delhi  Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyisa","family":"Deb","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine All India Institute of Medical Sciences\u2014Guwahati  Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dixa","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine All India Institute of Medical Sciences\u2014Rishikesh  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Dhingra","sequence":"additional","affiliation":[{"name":"Department of Hemato\u2010Oncology All India Institute of Medical Sciences\u2014Bhopal  Bhopal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uttam Kumar","family":"Nath","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine All India Institute of Medical Sciences\u2014Rishikesh  Rishikesh India"},{"name":"Department of Medical Oncology\/Hematology All India Institute of Medical Sciences  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine All India Institute of Medical Sciences\u2014Rishikesh  Rishikesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"453","volume-title":"Technical Manual","author":"Fung 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