{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T13:38:44Z","timestamp":1786714724369,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:00:00Z","timestamp":1770768000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43 TW010345"],"award-info":[{"award-number":["D43 TW010345"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["D43 TW010345"],"award-info":[{"award-number":["D43 TW010345"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To evaluate laboratory investigations for micronutrient deficiencies as the cause of anaemia prior to first\u2010time red blood cell transfusions in the medical emergency department (ED) of a large academic hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The ED is often the first point of contact for acutely ill anaemic patients, yet patient blood management principles are underutilised. Because micronutrient deficiencies are common, treatable causes of anaemia, they should be screened for to guide targeted treatment and reduce unnecessary transfusions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cross\u2010sectional study of 198 adult patients receiving first\u2010time transfusions in the medical emergency unit at Groote Schuur Hospital, South Africa, between April and October 2023. Laboratory investigations for iron, vitamin B12, and folate deficiencies were analysed and stratified by pre\u2010transfusion mean corpuscular volume (MCV). Iron deficiency was evaluated using three locally used criteria. Data about haematinic supplementation were also collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Only 29% of patients received a full micronutrient deficiency workup, while 39% had no testing. Iron deficiency was the most frequent abnormality, and up to 30% of these patients had normocytic indices. Iron supplementation rates were high, but many patients without iron deficiency also received iron.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The ED encounter should be used as an opportunity to initiate basic micronutrient deficiency screening for anaemia, regardless of MCV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.70068","type":"journal-article","created":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T11:58:52Z","timestamp":1770811132000},"page":"395-400","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["First\u2010time red blood cell transfusions in the emergency department: A deficiency in micronutrient testing"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5969-8554","authenticated-orcid":false,"given":"Andrea","family":"Coetzee","sequence":"first","affiliation":[{"name":"Division of Clinical Haematology, Department of Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6132-4717","authenticated-orcid":false,"given":"Karryn","family":"Brown","sequence":"additional","affiliation":[{"name":"Division of Clinical Haematology, Department of Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1408-2604","authenticated-orcid":false,"given":"Jessica","family":"Opie","sequence":"additional","affiliation":[{"name":"Division of Haematology, Department of Pathology University of Cape Town and National Health Laboratory Service  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0874-3082","authenticated-orcid":false,"given":"Jody","family":"Rusch","sequence":"additional","affiliation":[{"name":"Division of Chemical Pathology, Department of Pathology University of Cape Town and National Health Laboratory Service  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarie","family":"Kropman","sequence":"additional","affiliation":[{"name":"Division of Emergency Unit, Department of Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-3342","authenticated-orcid":false,"given":"Vernon","family":"Louw","sequence":"additional","affiliation":[{"name":"Division of Clinical Haematology, Department of Medicine University of Cape Town  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(23)00160\u20106"},{"key":"e_1_2_11_3_1","unstructured":"National Department of Health ICF.South Africa Demographic and Health Survey 2016.2019http:\/\/dhsprogram.com\/pubs\/pdf\/FR337\/FR337.pdf"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph20043584"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010015\u20100320\u20109"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445\u20105994.2011.02566.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.195552"},{"key":"e_1_2_11_8_1","volume-title":"Guidance on implementing patient blood management to improve global blood health status","author":"World Health Organization","year":"2024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201007\u2010746446"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(13)60808\u20109"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2019.07.006"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000005873"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.14092"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.4065\/78.10.1274"},{"key":"e_1_2_11_15_1","unstructured":"Elecsys Ferritin: Electrochemiluminescence Immunoassay (ECLIA) for the In Vitro Quantitative Determination of Ferritin in Human Serum and Plasma. 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