{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:55:28Z","timestamp":1792065328342,"version":"4.4.0"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Assess the safety and efficacy of restrictive transfusion in haemato\u2010oncological patients undergoing autologous haematopoietic stem cell transplantation (AHSCT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Restrictive transfusion is increasingly advocated within transfusion medicine to prevent over\u2010treatment, lower transfusion\u2010related adverse events and decrease healthcare costs. Yet there is a paucity of evidence regarding safe restrictive transfusion strategies in AHSCT patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Double\u2010unit transfusion at a haemoglobin threshold of 8\u2009g\/dL (i.e., liberal transfusion) is compared to single\u2010unit transfusion at a haemoglobin threshold of 7\u2009g\/dL (i.e., restrictive transfusion) by means of an interrupted time series study. RBC utilisation, survival and the occurrence of complications were assessed for the initial hospitalisation period and at the hundredth day following AHSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A group of 28 liberally transfused patients is compared to 18 restrictively transfused patients. Restrictively transfused patients received a median of 0.0 RBC units (IQR 0.0\u20131.0) and liberally transfused patients 2.0 RBC units (IQR 0.0\u20134.0) during hospitalisation (\n                      <jats:italic>U<\/jats:italic>\n                      \u2009=\u2009127.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The number of RBC concentrates administered by day +100 remained significantly lower for restrictively (0.0\u2009units, IQR 0.0\u20133.0) as opposed to liberally (2.0\u2009units, IQR 0.0\u20134.0) transfused patients (\n                      <jats:italic>U<\/jats:italic>\n                      \u2009=\u2009168.5,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.026). Survival and readmission rates did not differ significantly between both groups. The most prevalent complications, regardless of the applied transfusion protocol, included mucositis, fever of unknown origin and various infections.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Restrictive transfusion through combined lowering of the haemoglobin trigger to 7\u2009g\/dL and single\u2010unit transfusion effectively decreases RBC utilisation in a homogenous cohort of haemato\u2010oncology patients undergoing AHSCT without hampering safety.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.70078","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T05:34:05Z","timestamp":1775540045000},"page":"511-520","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Liberal versus restrictive transfusion in haemato\u2010oncological patients undergoing autologous stem cell transplantation: A single\u2010centre experience"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-8640-9482","authenticated-orcid":false,"given":"Ayman","family":"El Idrissi","sequence":"first","affiliation":[{"name":"Department of Clinical Haematology Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1062-2124","authenticated-orcid":false,"given":"Irene M. L. W.","family":"K\u00f6rver\u2010Keularts","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron J. M. H. E.","family":"Straat","sequence":"additional","affiliation":[{"name":"Central Diagnostic Laboratory Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik A. M.","family":"Beckers","sequence":"additional","affiliation":[{"name":"Department of Clinical Haematology Maastricht University Medical Centre  Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","DOI":"10.21037\/aob-22-45","article-title":"Patient blood management, past, present and future","volume":"9","author":"Gammon RR","year":"2024","journal-title":"Ann Blood"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1988.03410180108040"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199902113400601"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1808561"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1012452"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2019.01.003"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12070"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1406617"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14952"},{"key":"e_1_2_10_11_1","unstructured":"National Institute for Health and Care Excellence.Blood Transfusion NICE Guideline.2015https:\/\/www.nice.org.uk\/guidance\/ng24\/chapter\/recommendations#red-blood-cells."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011305.pub3"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.46989\/001c.94135"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.12914"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201001\u2010757930"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.14247"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.01836"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.047035"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13708"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2023.107058"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2024.150859"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15335"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17748"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01485.x"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2012.12.002"}],"container-title":["Transfusion Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.70078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/tme.70078","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tme.70078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:23:58Z","timestamp":1792063438000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tme.70078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,6]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/tme.70078"],"URL":"https:\/\/doi.org\/10.1111\/tme.70078","archive":["Portico"],"relation":{},"ISSN":["0958-7578","1365-3148"],"issn-type":[{"value":"0958-7578","type":"print"},{"value":"1365-3148","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,6]]},"assertion":[{"value":"2025-12-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}