{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:55:27Z","timestamp":1792065327269,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T00:00:00Z","timestamp":1777852800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>ABO incompatibility is common in allogeneic haematopoietic stem cell transplantation (HSCT) and may delay erythroid recovery and prolong transfusion support. Data correlating post\u2010transplant isoagglutinin kinetics with transfusion dependency is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analysed ABO\u2010incompatible allogeneic HSCTs performed between June 2008 and December 2023. Patients were classified as major, minor or bidirectional incompatibility. Serial Immunoglobulin M (IgM) and Immunoglobulin G (IgG) anti\u2010A and anti\u2010B isoagglutinin titres were monitored post\u2010transplant. Time to isoagglutinin disappearance, donor red blood cell (RBC) appearance and associations with packed red blood cell (PRBC) and single donor platelet (SDP) transfusion requirements were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 459 allogeneic HSCTs, 183 (39.9%) were ABO\u2010incompatible. Median isoagglutinin disappearance was 28\u2009days in major and 38.5\u2009days in bidirectional incompatibility, with delayed donor RBC appearance in the latter. Anti\u2010A isoagglutinins persisted longer than anti\u2010B. Persistent isoagglutinins correlated with increased early PRBC and SDP transfusion requirements.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Isoagglutinin kinetics vary by ABO incompatibility type and are associated with early transfusion dependency after HSCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.70080","type":"journal-article","created":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T01:27:14Z","timestamp":1777944434000},"page":"492-502","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isoagglutinin dynamics and transfusion dependency after\n                    <scp>ABO\u2010<\/scp>\n                    incompatible haematopoietic stem cell transplants"],"prefix":"10.1111","volume":"36","author":[{"given":"C. C.","family":"Archana","sequence":"first","affiliation":[{"name":"Department of Transfusion Medicine, ACTREC Tata Memorial Centre  Navi Mumbai India"},{"name":"Homi Bhabha National Institute (HBNI)  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8103-9161","authenticated-orcid":false,"given":"Suryatapa","family":"Saha","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, ACTREC Tata Memorial Centre  Navi Mumbai India"},{"name":"Homi Bhabha National Institute (HBNI)  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashank","family":"Ojha","sequence":"additional","affiliation":[{"name":"Department of Transfusion Medicine, ACTREC Tata Memorial Centre  Navi Mumbai India"},{"name":"Homi Bhabha National Institute (HBNI)  Mumbai 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