{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:07:07Z","timestamp":1778915227453,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n To describe the serological and molecular characteristics of a rare Gerbich\u2010negative phenotype detected in a Peruvian patient.<\/jats:p>\n <\/jats:sec>\n \n Background<\/jats:title>\n \n The Gerbich blood group (Ge) system includes high\u2010prevalence antigens (Ge2, Ge3, Ge4) encoded by the\n GYPC<\/jats:italic>\n gene. Absence of these antigens is extremely rare and has been reported mainly in Melanesian and Middle Eastern populations. To our knowledge, no molecularly confirmed cases have been reported in Peru.\n <\/jats:p>\n <\/jats:sec>\n \n Methods\/Materials<\/jats:title>\n \n A 65\u2010year\u2010old Peruvian man scheduled for orthopaedic surgery underwent pretransfusion testing, including an indirect antiglobulin test, antibody identification using Low Ionic Strength Solution (LISS)\/Coombs column agglutination cards at 37\u00b0C, papain\u2010treated reagent red cells, a direct antiglobulin test, autocontrol, differential alloadsorptions and neutralization studies. Anti\u2010Ge2 reference serum (IBGRL 4370) and molecular analysis of\n GYPC<\/jats:italic>\n were performed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Pretransfusion testing showed panagglutination with 2+ reactions in all reagent red cells; no reaction was observed with papain\u2010treated cells. The direct antiglobulin test, autocontrol and additional serological studies were negative. The antibody titre was 1:8. No reactivity was observed with anti\u2010Ge2, and molecular analysis identified the\n GE*01.\u201003.02<\/jats:italic>\n allele, responsible for the Gerbich phenotype (Ge:\u20132,\u20133,4).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This report describes a rare Gerbich\u2010negative phenotype in a Peruvian patient and highlights the importance of molecular typing for transfusion management.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/tme.70090","type":"journal-article","created":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T06:09:02Z","timestamp":1778911742000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A rare Gerbich\u2010negative (Ge:\u20132,\u20133,4) phenotype in a Peruvian patient"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1299-0964","authenticated-orcid":false,"given":"Jimmy Rinaldo Morales","family":"Del Pino","sequence":"first","affiliation":[{"name":"Hospital Nacional Edgardo Rebagliati Martins Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla Alexandra Paredes","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Nacional Edgardo Rebagliati Martins Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Enrique Penalillo","family":"Pimentel","sequence":"additional","affiliation":[{"name":"Hospital Nacional Edgardo Rebagliati Martins Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita Del Carmen Leyva","family":"Carlos","sequence":"additional","affiliation":[{"name":"Hospital Nacional Edgardo Rebagliati Martins Lima Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo Ampelio","family":"III Sagastegui Soto","sequence":"additional","affiliation":[{"name":"Hospital Nacional Edgardo Rebagliati Martins Lima 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