{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:49:03Z","timestamp":1782208143612,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Transfusion Medicine"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Transfusion\u2010associated graft\u2010versus\u2010host disease (Ta\u2010GvHD) is a rare, usually fatal complication of transfusing cellular components, prevented by irradiation. Congenital heart disease (CHD), particularly DiGeorge syndrome (del22q), may be associated with severe T\u2010cell immunodeficiency and Ta\u2010GvHD risk. British Society for Haematology guidelines (BSH, 2020) recommended targeted use of irradiated components for CHD based on immunological assessment; guideline adherence was unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To understand UK use of irradiated components for paediatric CHD surgery and barriers to BSH guideline implementation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      An electronic survey distributed to the 11\n                      <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>\n                      paediatric cardiothoracic surgical centres (January\u2010March 2024 inclusive).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 11 centres, 9 (82%) responded. Na\u00efve T\u2010cell enumeration, the BSH recommended test, was available to 8\/9 (89%), but used in 4\/9 (44%). 4\/9 (44%) and 5\/9 (56%) centres were willing to provide non\u2010irradiated components to neonates and children &gt;28\u2009days of age. Of these, 1\/4 (25%), 1\/5 (20%), and 4\/5 (80%) (for neonates, young children, and children from 2\u2009years) required criteria additional to BSH guidelines. 8\/9 (89%) centres reported ongoing barriers to guideline implementation, particularly challenges around pathway development and timely na\u00efve T\u2010cell enumeration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Overuse of irradiated components in surgery for patients with congenital heart disease is high: only 1\/3 of paediatric cardiac centres adhered to BSH guidance. Reasons included difficulties in immunological diagnostic pathway development. Collaboration between paediatric cardiothoracic, transfusion and immunology teams is required to address this.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/tme.70095","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:13:42Z","timestamp":1782206022000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implementation of\n                    <scp>BSH<\/scp>\n                    2020 irradiation guidelines for children with\n                    <scp>DiGeorge<\/scp>\n                    syndrome"],"prefix":"10.1111","author":[{"given":"Oliver","family":"Firth","sequence":"first","affiliation":[{"name":"NHS Blood and Transplant  Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6606-351X","authenticated-orcid":false,"given":"Philip","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia Alder Hey Children's Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Gennery","sequence":"additional","affiliation":[{"name":"Department of Paediatric Immunology, Translational and Clinical Research Institute Newcastle University  Newcastle Upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Alder Hey Children's Hospital  Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mele","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Royal Brompton Hospital Guy's &amp; St Thomas' NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Shackleton","sequence":"additional","affiliation":[{"name":"Alder Hey Children's Hospital  Liverpool 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