{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:05:03Z","timestamp":1780085103913,"version":"3.54.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,12,31]],"date-time":"2012-12-31T00:00:00Z","timestamp":1356912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the public health relevance of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>assa arenavirus and hantavirus infections in a subpopulation of recently febrile patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a human seroprevalence study, we enrolled 253 participants on the basis of reported high fever during the last 3\u00a0months. They represented roughly 20% of the population of <jats:styled-content style=\"fixed-case\">B<\/jats:styled-content>antou and <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>anganya villages. Comprehensive serological screening and confirmatory assays (enzyme\u2010linked immunosorbent assay, immunofluorescence assay, <jats:styled-content style=\"fixed-case\">W<\/jats:styled-content>estern blot analysis) with several <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>assa virus and hantavirus antigens were used to ensure high specificity and broad detection capacity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>assa <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>gG prevalence of 40.3% (102\/253) and a hantavirus <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>gG prevalence of 1.2% (3\/253). The <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>assa <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>gM prevalence reached 2.8% (7\/253).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>assa virus seroprevalence in recently febrile patients indicates that <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>assa fever is a significant public health problem in the region. Human hantavirus infections also occur in the region but their public health relevance remains to be determined.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12045","type":"journal-article","created":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T17:56:45Z","timestamp":1357063005000},"page":"366-371","source":"Crossref","is-referenced-by-count":26,"title":["Seroepidemiological study reveals regional co\u2010occurrence of <scp>L<\/scp>assa\u2010 and <scp>H<\/scp>antavirus antibodies in <scp>U<\/scp>pper <scp>G<\/scp>uinea, <scp>W<\/scp>est <scp>A<\/scp>frica"],"prefix":"10.1111","volume":"18","author":[{"given":"Boris","family":"Klempa","sequence":"first","affiliation":[{"name":"Institute of Medical Virology Charit\u00e9 School of Medicine Helmut\u2010Ruska\u2010Haus Berlin Germany"},{"name":"Institute of Virology Slovak Academy of Sciences Bratislava 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