{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:30:06Z","timestamp":1780551006551,"version":"3.54.1"},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Sickle cell disease (<jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>) is a chronic debilitating disorder affecting erythrocytes, which is especially prevalent throughout Sub\u2010<jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>aharan <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>frica and among individuals of <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>frican descent. Because malaria is thought to be a significant cause of morbidity and mortality in patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, malaria chemoprophylaxis is often recommended for these patients. In <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>, malaria chemoprophylaxis reduces malaria parasite count, anaemia and the need for blood transfusion, and improves clinical outcomes. However, the effectiveness of malaria chemoprophylaxis in the setting of <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> is based on a few studies conducted prior to the emergence of widespread antimalarial drug resistance. Consequently, it is uncertain what the optimal strategy for managing patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> in malarious areas should be. Despite the widespread use of hydroxyurea in non\u2010malarious regions, little is known about its effect in malaria\u2010endemic areas or on malaria\u2010related outcomes. On the one hand, hydroxyurea upregulates intercellular cell adhesion molecule 1 (<jats:styled-content style=\"fixed-case\">ICAM<\/jats:styled-content>\u20101), the cell surface receptor for adhesion of <jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>lasmodium falciparum<\/jats:italic>\u2010infected erythrocytes, and theoretically, it could enhance parasite replication. On the other hand, hydroxyurea increases levels of foetal haemoglobin, which is protective against malaria. We explore what is currently known about the interactions between <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content> and malaria and review the published literature on the efficacy of malaria chemoprophylaxis in <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>. We also consider alternative strategies, including hydroxyurea, in the reduction of malaria\u2010associated morbidity and mortality in patients with <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12056","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T10:22:45Z","timestamp":1358331765000},"page":"313-327","source":"Crossref","is-referenced-by-count":28,"title":["Systematic review of current and emerging strategies for reducing morbidity from malaria in sickle cell disease"],"prefix":"10.1111","volume":"18","author":[{"given":"Ehimen C.","family":"Aneni","sequence":"first","affiliation":[{"name":"Department of International Health Boston University School of Public Health Boston MA USA"},{"name":"Department of Medicine University College Hospital Ibadan Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davidson 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