{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T11:02:54Z","timestamp":1784890974419,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T00:00:00Z","timestamp":1358294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate the prevalence of nasopharyngeal bacterial colonisation (<jats:styled-content style=\"fixed-case\">NPBC<\/jats:styled-content>) patterns in young <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>anzanian <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010exposed infants and to analyse the influence of maternal <jats:styled-content style=\"fixed-case\">NPBC<\/jats:styled-content> and of the infant's <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> status on the <jats:styled-content style=\"fixed-case\">NPBC<\/jats:styled-content> pattern.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Longitudinal cohort study of neonates born to <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected mothers visiting <jats:styled-content style=\"fixed-case\">K<\/jats:styled-content>ilimanjaro <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hristian <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>edical <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>entre, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>anzania, between 2005 and 2009. Demographic and clinical data and nasopharyngeal bacterial cultures were obtained at the age of 6\u00a0weeks, 3 and 6\u00a0months, and at one time point, a paired mother\u2013infant nasopharyngeal swab was taken.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four hundred and twenty\u2010two swabs were taken from 338 eligible infants. At 6\u00a0weeks of age, colonisation rates were 66% for <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>taphylococcus aureus,<\/jats:italic> 56% for <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>treptococcus pneumoniae,<\/jats:italic> 50% for <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>oraxella catarrhalis and<\/jats:italic> 14% for <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>aemophilus influenzae<\/jats:italic>. Colonisation with <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0aureus<\/jats:italic> diminished over time and was more common in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected infants. <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0pneumoniae<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0influenzae<\/jats:italic> colonisation rose over time and was more prevalent in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010uninfected children. Co\u2010colonisation of <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0pneumoniae<\/jats:italic> with <jats:italic><jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>.\u00a0influenza<\/jats:italic>e or <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.\u00a0catarrhalis<\/jats:italic> was mostly noticed in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected infants. <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0pneumoniae<\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>.catarrhalis<\/jats:italic> colonisation of the mother was a risk factor for colonisation in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010uninfected infants, while maternal <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0aureus<\/jats:italic> colonisation was a risk factor for colonisation in <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010infected infants. Among the 104 <jats:italic><jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>.\u00a0pneumoniae<\/jats:italic> isolates, 19F was most prevalent, and 57 (55%) displayed capsular serotypes represented in the 13\u2010valent pneumococcal conjugate vaccine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">NPBC<\/jats:styled-content> was common in <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>anzanian <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\u2010exposed infants. The significant prevalence of pneumococcal vaccine serotypes colonising this paediatric population justifies the use of the 13\u2010valent pneumococcal vaccine to reduce the burden of pneumococcal invasive disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12057","type":"journal-article","created":{"date-parts":[[2013,1,16]],"date-time":"2013-01-16T10:22:49Z","timestamp":1358331769000},"page":"286-295","source":"Crossref","is-referenced-by-count":20,"title":["Dynamics of nasopharyngeal bacterial colonisation in <scp>HIV<\/scp>\u2010exposed young infants in <scp>T<\/scp>anzania"],"prefix":"10.1111","volume":"18","author":[{"given":"G. D.","family":"Kinabo","sequence":"first","affiliation":[{"name":"Department of Pediatrics Kilimanjaro Christian Medical Centre Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"van der Ven","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Medical Center Nijmegen The Netherlands"},{"name":"Nijmegen Institute for Infection, Inflammation and Immunity Radboud University Medical Centre Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Msuya","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kilimanjaro Christian Medical Centre Moshi Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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