{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T17:04:38Z","timestamp":1776359078511,"version":"3.51.2"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T00:00:00Z","timestamp":1360627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Chagas heart disease is developed as a result of the infection with <jats:italic><jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>rypanosoma cruzi<\/jats:italic>. Protein malnutrition contributes to secondary immunodeficiency. The aim of this study was to investigate the role of a low protein diet on the production of endothelin\u20101 and <jats:styled-content style=\"fixed-case\">CX<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>1 in blood and cardiac tissue samples in an experimental model with <jats:italic>T.\u00a0cruzi<\/jats:italic> infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fisher rats were submitted to low protein (6%) and normal protein (15%) diets and then infected with the Y strain of <jats:italic>T.\u00a0cruzi<\/jats:italic>. At days 15 and 120, parasites and immune cells were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The low protein diet reduced body weight and circulating serum proteins, but promoted elevation of <jats:styled-content style=\"fixed-case\">CX<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>1 and endothelin\u20101 levels in infected animals, which were unable to control blood parasitemia replication. In heart tissue, the low protein diet reduced cardiac <jats:styled-content style=\"fixed-case\">CX<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>1, endothelin\u20101 and leucocyte infiltration in the acute phase, in particular <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>68 and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>163 macrophage phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Together, these results highlight the participation of endothelin\u20101 and <jats:styled-content style=\"fixed-case\">CX<\/jats:styled-content>3<jats:styled-content style=\"fixed-case\">CL<\/jats:styled-content>1 in the inflammatory process of Chagas diesease, both being mediators partially controlled by the host nutritional status.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12071","type":"journal-article","created":{"date-parts":[[2013,2,12]],"date-time":"2013-02-12T06:08:47Z","timestamp":1360649327000},"page":"466-476","source":"Crossref","is-referenced-by-count":15,"title":["Protein deficiency alters <scp>CX<\/scp>3<scp>CL<\/scp>1 and endothelin\u20101 in experimental <i>Trypanosoma cruzi<\/i>\u2010induced cardiomyopathy"],"prefix":"10.1111","volume":"18","author":[{"given":"R\u00e9gia F.","family":"Martins","sequence":"first","affiliation":[{"name":"N\u00facleo de Pesquisas em Ci\u00eancias Biol\u00f3gicas Universidade Federal de Ouro Preto Ouro Preto Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patr\u00edcia M.","family":"Martinelli","sequence":"additional","affiliation":[{"name":"Departamento de Morfologia ICB Universidade Federal de Minas Gerais Belo Horizonte Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo M. 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