{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:15:51Z","timestamp":1790061351536,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T00:00:00Z","timestamp":1371081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To develop a new paediatric illness severity score, called inpatient triage, assessment and treatment (<jats:styled-content style=\"fixed-case\">ITAT<\/jats:styled-content>), for resource\u2010limited settings to identify hospitalised patients at highest risk of death and facilitate urgent clinical re\u2010evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a nested case\u2013control study at a Malawian referral hospital. The <jats:styled-content style=\"fixed-case\">ITAT<\/jats:styled-content> score was derived from four equally weighted variables, yielding a cumulative score between 0 and 8. Variables included oxygen saturation, temperature, and age\u2010adjusted heart and respiratory rates. We compared the <jats:styled-content style=\"fixed-case\">ITAT<\/jats:styled-content> score between cases (deaths) and controls (discharges) in predicting death within 2\u00a0days. Our analysis includes predictive statistics, bivariable and multivariable logistic regression, and calculation of data\u2010driven scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 54 cases and 161 controls were included in the analysis. The area under the receiver operating characteristic curve was 0.76. At an <jats:styled-content style=\"fixed-case\">ITAT<\/jats:styled-content> cut\u2010off of 4, the sensitivity, specificity and likelihood ratio were 0.44, 0.86 and 1.70, respectively. A cumulative <jats:styled-content style=\"fixed-case\">ITAT<\/jats:styled-content> score of 4 or higher was associated with increased odds of death (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 4.80; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 2.39\u20139.64). A score of 2 for all individual vital signs was a statistically significant independent predictor of death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We developed an inpatient triage tool (<jats:styled-content style=\"fixed-case\">ITAT<\/jats:styled-content>) appropriate for resource\u2010constrained hospitals that identifies high\u2010risk children after hospital admission. Further research is needed to study how best to operationalise <jats:styled-content style=\"fixed-case\">ITAT<\/jats:styled-content> in developing countries.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12137","type":"journal-article","created":{"date-parts":[[2013,6,13]],"date-time":"2013-06-13T04:51:50Z","timestamp":1371099110000},"page":"871-878","source":"Crossref","is-referenced-by-count":48,"title":["Development of a severity of illness scoring system (inpatient triage, assessment and treatment) for resource\u2010constrained hospitals in developing countries"],"prefix":"10.1111","volume":"18","author":[{"given":"Dan","family":"Olson","sequence":"first","affiliation":[{"name":"Department of Pediatrics University of Colorado Denver CO USA"},{"name":"University of North Carolina Project Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole L.","family":"Davis","sequence":"additional","affiliation":[{"name":"School of Public Health University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Milazi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Kamuzu Central Hospital Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Lufesi","sequence":"additional","affiliation":[{"name":"Malawi Ministry of Health Lilongwe Malawi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William C.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey A.","family":"Preidis","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine and Department of Pediatrics Texas Children's Hospital Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mina C.","family":"Hosseinipour","sequence":"additional","affiliation":[{"name":"University of North Carolina Project Lilongwe Malawi"},{"name":"Department of Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"McCollum","sequence":"additional","affiliation":[{"name":"University of North Carolina Project Lilongwe Malawi"},{"name":"Department of Pediatrics Johns Hopkins School of Medicine Baltimore MD 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