{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:31:02Z","timestamp":1790688662880,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,6,21]],"date-time":"2013-06-21T00:00:00Z","timestamp":1371772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the genetic determinants for developing tuberculosis in <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>udan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Case study of 232 patients with tuberculosis and 206 healthy matched controls from <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>udan. In the study population, three single nucleotide polymorphisms (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s) in the promoter regions of <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>5 and two in the promoter region of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 were genotyped using polymerase chain reaction and restriction fragment length polymorphism (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">RFLP<\/jats:styled-content>). These five <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>s influence the expression of these genes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were significant differences in allele distribution for <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>5 \u201028 C\/G (rs 2280788) and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 \u2010592 A\/C (rs1800872) in patients with tuberculosis compared with healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This indicates that the genotypes obtained for <jats:styled-content style=\"fixed-case\">CCL<\/jats:styled-content>5 and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201010 are associated with an increased risk of developing active <jats:styled-content style=\"fixed-case\">TB<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12141","type":"journal-article","created":{"date-parts":[[2013,6,22]],"date-time":"2013-06-22T04:22:07Z","timestamp":1371874927000},"page":"1119-1127","source":"Crossref","is-referenced-by-count":22,"title":["Association of <scp>IL<\/scp>\u201010 and <scp>CCL<\/scp>5 single nucleotide polymorphisms with tuberculosis in the <scp>S<\/scp>udanese population"],"prefix":"10.1111","volume":"18","author":[{"given":"Najwa","family":"Mhmoud","sequence":"first","affiliation":[{"name":"Mycetoma Research Centre University of Khartoum Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Fahal","sequence":"additional","affiliation":[{"name":"Mycetoma Research Centre University of Khartoum Khartoum Sudan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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