{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T02:24:09Z","timestamp":1793931849983,"version":"4.8.0"},"reference-count":11,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T00:00:00Z","timestamp":1376352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Tropical Med Int Health"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Schistosomiasis is known to occur in preschool\u2010aged children, but achieving accurate dosing of praziquantel in its current form is challenging. While waiting for a paediatric formulation, there is a need to develop a means for using the available products to treat this age group. Current 600\u2010mg tablets are differently scored to give units of 150\u00a0mg (a quarter of a tablet) or 300\u00a0mg (half a tablet).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We examined several dosing schemes to dose accurately (40\u201060\u00a0mg\/kg) children aged 3\u201372\u00a0months (weight range 4\u201325\u00a0kg, based on available weight\u2010for\u2010age growth references from sub\u2010Saharan Africa and Brazil, <jats:italic>n<\/jats:italic>\u00a0=\u00a0106,230).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Adequate dosing can be achieved with formulations that can be split into four 150\u00a0mg quarters for children weighing 5\u00a0kg or more, and with tablets than can be split into two 300\u00a0mg halves for children weighing 10\u00a0kg or more. Giving \u00bd tablet for 5\u20137\u00a0kg; \u00be tablet for 8\u201310\u00a0kg; 1 tablet for 11\u201315\u00a0kg; 1 \u00bd tablet for 16\u201321\u00a0kg; and two tablets for 22\u201325\u00a0kg will have 100% of subjects correctly dosed within the target 40\u201360\u00a0mg\/kg range.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Formulations that can be divided into four parts (to give 150\u00a0mg increments) are preferred for children weighing less than 11\u00a0kg; the same dosing can be applied with 600\u00a0mf praziquantel formulations that can be divided into four quarters or two halves from 11\u00a0kg body weight.<\/jats:p><\/jats:sec>","DOI":"10.1111\/tmi.12152","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T04:54:34Z","timestamp":1376369674000},"page":"1085-1089","source":"Crossref","is-referenced-by-count":20,"title":["Practical dosing of praziquantel for schistosomiasis in preschool\u2010aged children"],"prefix":"10.1111","volume":"18","author":[{"given":"Piero L.","family":"Olliaro","sequence":"first","affiliation":[{"name":"UNICEF\/UNDP\/World Bank\/WHO Special Programme for Research &amp; Training in Tropical Diseases (TDR) Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Vaillant","sequence":"additional","affiliation":[{"name":"Methodology and Statistics Unit Centre de Recherche Public \u2013 Sant\u00e9 (CRP\u2010Sant\u00e9) Strassen Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Liverpool School of Tropical Medicine Liverpool UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Montresor","sequence":"additional","affiliation":[{"name":"Department of Control of Neglected Tropical Diseases World Health Organization (WHO) Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lester","family":"Chitsulo","sequence":"additional","affiliation":[{"name":"Department of Control of Neglected Tropical Diseases World Health Organization (WHO) Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3667"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000053.pub2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD000528.pub2"},{"key":"e_1_2_6_5_1","volume-title":"Development of Age and Height Based Dosing Regimens for Antimalarials as Alternatives to Weight\u2010Based Dose Regimens [Doctoral Thesis]","author":"Hayes DJ","year":"2011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0035-9203(01)90034-3"},{"key":"e_1_2_6_7_1","unstructured":"PharmaTI(2013)Schistosomiasis Treatment for Preschool Children. Leiden [cited 2013 05\/04\/2013]. Available from:http:\/\/www.tipharma.com\/pharmaceutical-research-projects\/infectious-diseases\/schistosomiasis.html."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inhe.2012.03.003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2007.01.005"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.02.001"},{"key":"e_1_2_6_11_1","volume-title":"Preventive Chemotherapy in Human Helminthiasis: Coordinated Use of Anthelminthic Drugs in Control Interventions: A Manual for Health Professionals and Programme Managers","author":"World Health Organization","year":"2006"},{"key":"e_1_2_6_12_1","unstructured":"World Health Organization(2010)Report of a Meeting to Review the Results of Studies on the Treatment of Schistosomiasis in Pre\u2010School\u2010Age Children. 13\u201314 September 2010. Report No Geneva Switzerland."}],"container-title":["Tropical Medicine &amp; International Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.12152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Ftmi.12152","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/tmi.12152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T13:02:44Z","timestamp":1696165364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/tmi.12152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,13]]},"references-count":11,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1111\/tmi.12152"],"URL":"https:\/\/doi.org\/10.1111\/tmi.12152","archive":["Portico"],"relation":{},"ISSN":["1360-2276","1365-3156"],"issn-type":[{"value":"1360-2276","type":"print"},{"value":"1365-3156","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,13]]}}}